Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | excision repair cross-complementing 1 ercc1, putative | 0.006 | 1 | 1 |
Brugia malayi | ERCC4 domain containing protein | 0.0043 | 0.4902 | 1 |
Plasmodium falciparum | ERCC1 nucleotide excision repair protein, putative | 0.006 | 1 | 1 |
Trypanosoma brucei | DNA repair protein, putative | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | excision repair cross-complementing 1 ercc1 | 0.006 | 1 | 1 |
Entamoeba histolytica | DNA excision repair protein, putative | 0.006 | 1 | 1 |
Plasmodium vivax | ERCC1 nucleotide excision repair protein, putative | 0.006 | 1 | 1 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | helix-hairpin-helix domain-containing protein family protein | 0.006 | 1 | 1 |
Echinococcus multilocularis | DNA excision repair protein ERCC 1 | 0.006 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23 uM | Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.