Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.053 | 0.5 | 0.5 | |
Brugia malayi | Trypsin family protein | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Onchocerca volvulus | 0.053 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.053 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.053 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Echinococcus granulosus | Mastin | 0.053 | 0.5 | 0.5 |
Onchocerca volvulus | 0.053 | 0.5 | 0.5 | |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Onchocerca volvulus | 0.053 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Onchocerca volvulus | 0.053 | 0.5 | 0.5 | |
Echinococcus multilocularis | Mastin | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.053 | 0.5 | 0.5 |
Onchocerca volvulus | 0.053 | 0.5 | 0.5 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.053 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.053 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.053 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.053 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.053 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.053 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Intrinsic activity (functional) | = 45 % | Agonist activity was assessed by measurement of cAMP accumulation levels in CHO membranes expressing human beta3 receptor | ChEMBL. | 11714606 |
Intrinsic activity (functional) | = 45 % | Agonist activity was assessed by measurement of cAMP accumulation levels in CHO membranes expressing human beta3 receptor | ChEMBL. | 11714606 |
Ki (binding) | = 2400 nM | Binding affinity to CHO cells expressing the cloned human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindolol | ChEMBL. | 11714606 |
Ki (binding) | = 2400 nM | Binding affinity to CHO cells expressing the cloned human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindolol | ChEMBL. | 11714606 |
Selectivity ratio (binding) | = 0.6 | Tested for binding selectivity to beta3 adrenoreceptor versus beta2 adrenoreceptor | ChEMBL. | 11714606 |
Selectivity ratio (binding) | = 4 | Tested for binding selectivity to beta3 adrenoreceptor versus beta1 adrenoreceptor | ChEMBL. | 11714606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.