Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Brugia malayi | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.378 | 0.378 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0015 | 0.0731 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.378 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0015 | 0.0731 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.9041 | 0.9223 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.378 | 0.5 |
Brugia malayi | hypothetical protein | 0.0197 | 0.9803 | 1 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0015 | 0.0731 | 0.5 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.02 | 0.9972 | 0.9972 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.02 | 0.9972 | 0.9972 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.02 | 0.9972 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.02 | 0.9972 | 1 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0731 | 0.5 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0015 | 0.0731 | 0.0731 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0015 | 0.0731 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.2139 | 1 | |
Schistosoma mansoni | single-minded | 0.0059 | 0.29 | 0.29 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0015 | 0.0731 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.29 | 0.2959 |
Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.2139 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0015 | 0.0731 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.378 | 0.378 |
Echinococcus granulosus | single minded 2 | 0.0043 | 0.2139 | 0.2145 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0015 | 0.0731 | 0.0733 |
Mycobacterium leprae | Possible regulatory protein | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0015 | 0.0731 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.378 | 0.379 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.02 | 0.9972 | 1 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0015 | 0.0731 | 0.0746 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0731 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.378 | 0.378 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.9041 | 0.9223 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.0731 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0015 | 0.0731 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0015 | 0.0731 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.29 | 0.29 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0015 | 0.0731 | 0.5 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0015 | 0.0731 | 0.0733 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0015 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0731 | 0.0746 |
Brugia malayi | hypothetical protein | 0.0076 | 0.378 | 0.3856 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.378 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.2139 | 0.2182 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0015 | 0.0731 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.0731 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.378 | 0.5 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0015 | 0.0731 | 0.5 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0043 | 0.2139 | 0.2139 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.9803 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 20 uM | Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by SRB assay | ChEMBL. | 23153200 |
IC50 (binding) | = 1.07 uM | Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assay | ChEMBL. | 23153200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.