Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | breakpoint cluster region | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | active breakpoint cluster region | Get druggable targets OG5_131841 | All targets in OG5_131841 |
Echinococcus multilocularis | active breakpoint cluster region | Get druggable targets OG5_131841 | All targets in OG5_131841 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.024 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.024 | 0.4059 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.024 | 0.4059 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.024 | 0.4059 | 0.7931 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.024 | 0.4059 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0131 | 0.0328 | 0.0808 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0414 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.024 | 0.4059 | 0.7931 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | nuclear receptor NHR-88 | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | FTZ F1 alpha | 0.024 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | nuclear hormone receptor | 0.024 | 0.4059 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.024 | 0.4059 | 0.7931 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | nuclear hormone receptor | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.024 | 0.4059 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.024 | 0.4059 | 0.3858 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.024 | 0.4059 | 0.3858 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | steroid hormone receptor | 0.0403 | 0.9608 | 0.9594 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.024 | 0.4059 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.024 | 0.4059 | 0.3858 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.024 | 0.4059 | 0.7931 |
Echinococcus granulosus | FTZ F1 alpha | 0.024 | 0.4059 | 0.7931 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.024 | 0.4059 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.024 | 0.4059 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.024 | 0.4059 | 0.3858 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.024 | 0.4059 | 0.3858 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.024 | 0.4059 | 0.7931 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.024 | 0.4059 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.024 | 0.4059 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0131 | 0.0328 | 0.0641 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.024 | 0.4059 | 0.3858 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.024 | 0.4059 | 0.7931 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.024 | 0.4059 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.024 | 0.4059 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.024 | 0.4059 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.024 | 0.4059 | 0.7931 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.024 | 0.4059 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.024 | 0.4059 | 0.7931 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.024 | 0.4059 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.024 | 0.4059 | 0.3858 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.024 | 0.4059 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0403 | 0.9608 | 0.9594 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.024 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.024 | 0.4059 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0271 | 0.5118 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | coup transcription factor | 0.024 | 0.4059 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.024 | 0.4059 | 0.3858 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.024 | 0.4059 | 0.3858 |
Schistosoma mansoni | thyroid hormone receptor | 0.024 | 0.4059 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.024 | 0.4059 | 0.3858 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 302 nM | Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assay | ChEMBL. | 23088644 |
IC50 (functional) | = 800 nM | Antiproliferative activity against imatinib-resistant human K562 cells expressing Bcr-Abl Q252H mutant after 72 hrs by CCK-8 assay | ChEMBL. | 23088644 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23088644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.