Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | kinase insert domain protein receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0105 | 0.4714 | 1 |
Onchocerca volvulus | 0.0105 | 0.4714 | 0.4736 | |
Echinococcus granulosus | Mastin | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Onchocerca volvulus | 0.0105 | 0.4714 | 0.4736 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0214 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0105 | 0.4714 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0105 | 0.4714 | 0.4714 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.4714 | 0.4714 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0105 | 0.4714 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.4714 | 0.4714 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0105 | 0.4714 | 0.4714 |
Onchocerca volvulus | 0.0105 | 0.4714 | 0.4736 | |
Echinococcus granulosus | enteropeptidase | 0.0105 | 0.4714 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0105 | 0.4714 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0213 | 0.9952 | 1 |
Onchocerca volvulus | 0.0208 | 0.9716 | 0.9763 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0105 | 0.4714 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0105 | 0.4714 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0105 | 0.4714 | 1 |
Onchocerca volvulus | 0.0105 | 0.4714 | 0.4736 | |
Loa Loa (eye worm) | trypsin family protein | 0.0105 | 0.4714 | 0.4714 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.4714 | 0.4714 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.4714 | 0.4714 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.4714 | 0.4714 |
Echinococcus multilocularis | Mastin | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.4714 | 1 |
Onchocerca volvulus | 0.0105 | 0.4714 | 0.4736 | |
Onchocerca volvulus | 0.0105 | 0.4714 | 0.4736 | |
Mycobacterium ulcerans | hypothetical protein | 0.0105 | 0.4714 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.4714 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0009 | 0.0062 | 0.0131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | ChEMBL. | 10956210 |
Log IC50 (binding) | = 5.2 | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | ChEMBL. | 10956210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.