Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0249 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0249 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0249 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.5828 | 0.683 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0249 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0249 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 0.7868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0757 | 0.8533 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.702 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0249 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0844 | 1 | 1 |
Onchocerca volvulus | 0.0844 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0249 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0249 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0249 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0844 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0683 | 0.7295 | 0.8549 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0249 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 0.7868 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0249 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0249 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0249 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.21 uM | Inhibition of human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate addition measured for 15 mins by Amplex red assay | ChEMBL. | 23153812 |
IC50 (binding) | = 7.55 uM | Inhibition of human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate addition measured for 15 mins by Amplex red assay | ChEMBL. | 23153812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.