Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aminopeptidase, putative | 0.0386 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0386 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0386 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0386 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0386 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0386 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0925 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.1175 | 0.8533 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0386 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0386 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.1311 | 1 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.1311 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0386 | 0 | 0.5 |
Onchocerca volvulus | 0.1311 | 1 | 1 | |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0386 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0386 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0386 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0386 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0386 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1061 | 0.7295 | 0.8549 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 5.6 % | Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP response element (MRE/CRE)-driven reporter gene assay relative to 10 nM GLP1 | ChEMBL. | 22103243 |
Inhibition (binding) | = 29.8 % | Inhibition of [125I]Exendin (9-39) binding to rat GLP1R expressed in HEK293 cells | ChEMBL. | 22103243 |
Inhibition (binding) | = 37.6 % | Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cells relative to untreated control | ChEMBL. | 22103243 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.