Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.109 | 0.109 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.6682 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.109 | 0.109 |
Mycobacterium ulcerans | hypothetical protein | 0.015 | 0.8075 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.2571 | 0.3848 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.6682 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0178 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.109 | 0.1631 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.6682 | 0.6682 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0178 | 1 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0178 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.109 | 0.109 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.015 | 0.8075 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.4132 | 0.4132 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.109 | 0.109 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.6682 | 0.6682 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2571 | 0.2571 |
Schistosoma mansoni | alkaline phosphatase | 0.0178 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.109 | 0.109 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.4787 | 0.7163 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.6682 | 0.6682 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.6682 | 1 |
Brugia malayi | TAR-binding protein | 0.013 | 0.6682 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.4787 | 0.7163 |
Echinococcus granulosus | alkaline phosphatase | 0.0178 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.4787 | 0.7163 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.015 | 0.8075 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.6682 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.4787 | 0.7163 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.6682 | 0.6682 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.109 | 0.109 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.6682 | 0.6682 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0178 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.013 | 0.6682 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.6682 | 0.6682 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.015 | 0.8075 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.109 | 0.109 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.6682 | 0.6682 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0178 | 1 | 1 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.015 | 0.8075 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.109 | 0.1631 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0178 | 1 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0178 | 1 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.015 | 0.8075 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2571 | 0.3848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | >= 150 % | Elevation of total ceramide level in human MDA-MB-231 cells at 50 uM after 24 hrs by LC-MS/MS analysis relative to control | ChEMBL. | 23312611 |
Inhibition (binding) | Inhibition of recombinant human aCDase expressed in Sf9 cells using fluorescently-labeled acyl-NBD-C12-ceramide as substrate at 80 uM after 8 hrs by fluorescence assay | ChEMBL. | 22989912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.