Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.5 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 18.9 % | Antagonist activity at wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 assessed as testosterone induced luciferase activity at 10 uM after 18 hrs relative untreated control | ChEMBL. | 22746350 |
IC50 (binding) | = 6.65 | Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation assay | ChEMBL. | 22746350 |
Inhibition (binding) | Inhibition of Photinus pyralis recombinant luciferase at 10 uM incubated for 20 mins | ChEMBL. | 22746350 | |
Inhibition (binding) | = 91.8 % | Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation assay relative to untreated control | ChEMBL. | 22746350 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.