Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0034 | 0.0032 |
Onchocerca volvulus | 0.0464 | 0.0735 | 0.565 | |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.08 | 0.1292 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0064 | 0.0063 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0013 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0464 | 0.0735 | 0.0699 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0034 | 0.0026 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0002 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.08 | 0.1292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0013 | 0.0011 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0464 | 0.0735 | 0.0734 |
Loa Loa (eye worm) | glutamate receptor | 0.194 | 0.3175 | 0.3173 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0013 | 0.5 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0464 | 0.0735 | 0.0892 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0013 | 1 |
Schistosoma mansoni | hypothetical protein | 0.08 | 0.1292 | 0.1367 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0464 | 0.0735 | 0.0699 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.413 | 0.6795 | 0.7349 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0013 | 0.0011 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0464 | 0.0735 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0064 | 0.0064 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0464 | 0.0735 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0064 | 0.0063 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.4931 | 0.8117 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.2403 | 0.3941 | 0.4847 |
Schistosoma mansoni | tyrosine kinase | 0.0464 | 0.0735 | 0.0762 |
Leishmania major | extracellular receptor, putative | 0.0464 | 0.0735 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.4467 | 0.7351 | 0.9055 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.1292 | 0.129 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0464 | 0.0735 | 0.0734 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.08 | 0.1292 | 0.1578 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0013 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.2403 | 0.3941 | 0.4246 |
Echinococcus granulosus | tyrosine kinase | 0.0464 | 0.0735 | 0.0699 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0464 | 0.0735 | 0.0699 |
Echinococcus multilocularis | tyrosine kinase | 0.0464 | 0.0735 | 0.0699 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0013 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0013 | 0.0011 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0464 | 0.0735 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.413 | 0.6795 | 0.6782 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0016 | 1 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0464 | 0.0735 | 0.565 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0013 | 1 |
Onchocerca volvulus | 0.0505 | 0.0804 | 0.6187 | |
Loa Loa (eye worm) | glutamate receptor | 0.4931 | 0.8117 | 0.8117 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.0039 | 0.0005 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0464 | 0.0735 | 0.0699 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0064 | 0.0064 |
Echinococcus granulosus | glutamate receptor 2 | 0.0464 | 0.0735 | 0.0699 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0016 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0464 | 0.0735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0016 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0013 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0464 | 0.0735 | 0.0762 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.0039 | 0.0005 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.0039 | 0.0032 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0464 | 0.0735 | 0.0699 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0464 | 0.0735 | 0.0699 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0013 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.1264 | 0.2058 | 0.2056 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0013 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.0039 | 0.0005 |
Schistosoma mansoni | tyrosine kinase | 0.0464 | 0.0735 | 0.0762 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0464 | 0.0735 | 0.0699 |
Onchocerca volvulus | 0.0464 | 0.0735 | 0.565 | |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0016 | 0.0038 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0013 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1264 | 0.2058 | 0.2056 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0016 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.413 | 0.6795 | 0.6782 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0016 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0464 | 0.0735 | 0.0699 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0464 | 0.0735 | 0.0892 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0013 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0464 | 0.0735 | 0.0699 |
Schistosoma mansoni | protein kinase | 0.0464 | 0.0735 | 0.0762 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.1264 | 0.2058 | 0.2523 |
Echinococcus granulosus | glutamate receptor 2 | 0.0464 | 0.0735 | 0.0699 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0002 | 0.139 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.1264 | 0.2058 | 0.2056 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0464 | 0.0735 | 0.0699 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0505 | 0.0804 | 0.0802 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.08 | 0.1292 | 0.1258 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0735 | 0.0734 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0464 | 0.0735 | 0.0699 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0464 | 0.0735 | 0.0699 |
Brugia malayi | hypothetical protein | 0.0464 | 0.0735 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0016 | 0.0014 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0464 | 0.0735 | 0.0699 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0464 | 0.0735 | 0.0699 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.0039 | 0.0037 |
Brugia malayi | Pax transcription factor protein 2 | 0.0505 | 0.0804 | 0.0976 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.08 | 0.1292 | 0.1258 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0464 | 0.0735 | 0.0734 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0464 | 0.0735 | 0.0892 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.5606 | 0.9234 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0464 | 0.0735 | 0.0699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Cytotoxicity against human PC3 cells after 72 hrs by SRB assay | ChEMBL. | 23044367 |
Inhibition (binding) | = 8.1 % | Inhibition of Influenza A virus (A/RI/5+/1957(H2N2)) recombinant neuraminidase using MUNANA as substrate at 100 uM after 30 mins | ChEMBL. | 24613627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.