Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6678 | 0.6678 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0153 | 0.7455 | 0.5 |
Brugia malayi | RNA binding protein | 0.0141 | 0.6678 | 0.631 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0153 | 0.7455 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6678 | 0.6678 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2172 | 0.2172 |
Loa Loa (eye worm) | TAR-binding protein | 0.0141 | 0.6678 | 0.5756 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.4229 | 0.3589 |
Brugia malayi | hypothetical protein | 0.008 | 0.2792 | 0.1993 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.4229 | 0.2627 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.2792 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2792 | 0.0792 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.2792 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0141 | 0.6678 | 0.6678 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.2792 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0141 | 0.6678 | 0.631 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0153 | 0.7455 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.2792 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0141 | 0.6678 | 0.631 |
Loa Loa (eye worm) | RNA binding protein | 0.0141 | 0.6678 | 0.5756 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.2792 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6678 | 0.6678 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.2172 | 0.1305 |
Mycobacterium ulcerans | hypothetical protein | 0.0153 | 0.7455 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6678 | 0.6678 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0153 | 0.7455 | 0.5 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0153 | 0.7455 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0141 | 0.6678 | 0.5756 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.2792 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0141 | 0.6678 | 0.6678 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.2792 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.6678 | 0.6678 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.4229 | 0.2627 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.2792 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.4229 | 0.3589 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 13.57 uM | Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay | ChEMBL. | 23036956 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23036956 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.