Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0766 | 0.1993 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0109 | 0.0925 | 0.2793 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0097 | 0.0766 | 0.2312 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.0766 | 0.0766 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.2129 |
Brugia malayi | Histone deacetylase family protein | 0.0097 | 0.0766 | 0.1762 |
Leishmania major | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0071 | 0.0423 | 0.0423 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0097 | 0.0766 | 0.2312 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0109 | 0.0925 | 0.0925 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Leishmania major | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Brugia malayi | Histone deacetylase 1 | 0.0292 | 0.3311 | 0.7623 |
Echinococcus granulosus | histone deacetylase 8 | 0.0097 | 0.0766 | 0.1762 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0097 | 0.0766 | 0.2312 |
Plasmodium vivax | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0292 | 0.3311 | 0.8618 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0097 | 0.0766 | 0.2312 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0423 | 0.1102 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0097 | 0.0766 | 0.1762 |
Echinococcus granulosus | histone deacetylase 3 | 0.0292 | 0.3311 | 0.7623 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0097 | 0.0766 | 0.1993 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0109 | 0.0925 | 0.2793 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.2129 |
Trypanosoma brucei | histone deacetylase 2 | 0.0097 | 0.0766 | 0.2312 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.0925 |
Brugia malayi | hypothetical protein | 0.0109 | 0.0925 | 0.2129 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0292 | 0.3311 | 0.7623 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0109 | 0.0925 | 0.2793 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.03 | 0.3419 | 0.8898 |
Brugia malayi | histone deacetylase 11 | 0.0097 | 0.0766 | 0.1762 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0071 | 0.0423 | 0.1278 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0292 | 0.3311 | 0.8618 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0292 | 0.3311 | 0.3311 |
Trypanosoma brucei | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0109 | 0.0925 | 0.2793 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2917 | 0.7593 |
Brugia malayi | Histone deacetylase family protein | 0.0097 | 0.0766 | 0.1762 |
Plasmodium falciparum | histone deacetylase 2 | 0.0097 | 0.0766 | 0.2312 |
Onchocerca volvulus | 0.0109 | 0.0925 | 0.2129 | |
Echinococcus multilocularis | aminopeptidase N | 0.0371 | 0.4343 | 0.4343 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0292 | 0.3311 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0097 | 0.0766 | 0.2312 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0109 | 0.0925 | 0.2793 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.2129 |
Schistosoma mansoni | histone deacetylase | 0.0292 | 0.3311 | 1 |
Leishmania major | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.0766 | 0.0766 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0109 | 0.0925 | 0.2793 |
Echinococcus granulosus | histone deacetylase 1 | 0.0292 | 0.3311 | 0.7623 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.0766 | 0.1762 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0109 | 0.0925 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0423 | 0.1102 |
Leishmania major | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Plasmodium vivax | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0292 | 0.3311 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0097 | 0.0766 | 0.1762 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.3311 | 0.8618 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0097 | 0.0766 | 0.1993 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0109 | 0.0925 | 0.2793 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0097 | 0.0766 | 0.0766 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0109 | 0.0925 | 0.2793 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.0766 | 0.0766 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0109 | 0.0925 | 0.2793 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0097 | 0.0766 | 0.2312 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0292 | 0.3311 | 0.3311 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0097 | 0.0766 | 0.2312 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.0925 |
Trypanosoma brucei | histone deacetylase 4 | 0.0097 | 0.0766 | 0.2312 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.0766 | 0.1762 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0292 | 0.3311 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.0925 |
Schistosoma mansoni | histone deacetylase | 0.0292 | 0.3311 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Trypanosoma brucei | histone deacetylase 1 | 0.0292 | 0.3311 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0292 | 0.3311 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0097 | 0.0766 | 0.2312 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0071 | 0.0423 | 0.1278 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0109 | 0.0925 | 0.2793 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.0766 | 0.1762 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0292 | 0.3311 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0292 | 0.3311 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0097 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | aminopeptidase N | 0.0109 | 0.0925 | 0.2407 |
Onchocerca volvulus | 0.0371 | 0.4343 | 1 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.0925 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0292 | 0.3311 | 0.7623 |
Echinococcus granulosus | aminopeptidase N | 0.0371 | 0.4343 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0097 | 0.0766 | 0.0766 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0109 | 0.0925 | 0.2793 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0097 | 0.0766 | 0.2312 |
Brugia malayi | Peptidase family M1 containing protein | 0.0371 | 0.4343 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0292 | 0.3311 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Plasmodium falciparum | histone deacetylase 1 | 0.0292 | 0.3311 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0292 | 0.3311 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0097 | 0.0766 | 0.2312 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0109 | 0.0925 | 0.2793 |
Loa Loa (eye worm) | histone deacetylase | 0.0097 | 0.0766 | 0.1993 |
Echinococcus granulosus | histone deacetylase 7 | 0.0097 | 0.0766 | 0.1762 |
Brugia malayi | Peptidase family M1 containing protein | 0.0109 | 0.0925 | 0.2129 |
Giardia lamblia | Histone deacetylase | 0.0292 | 0.3311 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.3842 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.0766 | 0.2312 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0292 | 0.3311 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0109 | 0.0925 | 0.2129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes at 10 nM | ChEMBL. | 23102207 |
Inhibition (binding) | = 54 % | Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranes at 1 uM | ChEMBL. | 23102207 |
Ki (binding) | Displacement of [3H]GR113808 from human recombinant 5HT4R expressed in HEK293T cells | ChEMBL. | 23102207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.