Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | succinate receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | histone deacetylase 4 | 0.0097 | 0.1961 | 0.1961 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | histone deacetylase | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0097 | 0.1961 | 0.1961 |
Leishmania major | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | histone deacetylase 7 | 0.0097 | 0.1961 | 0.1961 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1742 | 0.1742 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0097 | 0.1961 | 0.1961 |
Brugia malayi | Histone deacetylase family protein | 0.0097 | 0.1961 | 0.1961 |
Loa Loa (eye worm) | histone deacetylase | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma brucei | histone deacetylase 3 | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | aminopeptidase N | 0.0128 | 0.2989 | 0.2989 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0104 | 0.2181 | 0.2181 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0097 | 0.1961 | 0.1961 |
Onchocerca volvulus | 0.0128 | 0.2989 | 1 | |
Leishmania major | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Brugia malayi | Histone deacetylase family protein | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.1961 | 0.1961 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0097 | 0.1961 | 0.6561 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.1961 | 0.1961 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | histone deacetylase | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma brucei | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.2551 | 0.2551 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | histone deacetylase 8 | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.1961 | 0.1961 |
Brugia malayi | histone deacetylase 11 | 0.0097 | 0.1961 | 0.1961 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0097 | 0.1961 | 0.1961 |
Echinococcus multilocularis | aminopeptidase N | 0.0128 | 0.2989 | 0.2989 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.1961 | 0.1961 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.1961 | 0.1961 |
Trypanosoma brucei | histone deacetylase 2 | 0.0097 | 0.1961 | 0.1961 |
Brugia malayi | Peptidase family M1 containing protein | 0.0128 | 0.2989 | 0.2989 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0097 | 0.1961 | 0.1961 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 31 nM | Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay | ChEMBL. | 21571530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.