Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0328 | 0.475 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT1 | 0.0328 | 0.475 | 0.5 |
Plasmodium falciparum | protein arginine N-methyltransferase 1 | 0.0328 | 0.475 | 0.5 |
Plasmodium vivax | protein arginine N-methyltransferase 1, putative | 0.0328 | 0.475 | 0.5 |
Echinococcus multilocularis | protein arginine methyltransferase | 0.0328 | 0.475 | 0.5 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0328 | 0.475 | 1 |
Echinococcus multilocularis | protein arginine N methyltransferase 8 | 0.0328 | 0.475 | 0.5 |
Echinococcus granulosus | protein arginine N methyltransferase 8 | 0.0328 | 0.475 | 0.5 |
Echinococcus granulosus | protein arginine methyltransferase | 0.0328 | 0.475 | 0.5 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0328 | 0.475 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0328 | 0.475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 uM | Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorimetric analysis | ChEMBL. | 22642300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.