Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Vaccinia virus (strain Copenhagen) (VACV) | Uracil-DNA glycosylase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1616 | 0.1616 |
Entamoeba histolytica | uracil-DNA glycosylase, putative | 0.0075 | 0.3252 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0347 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0347 | 0.0347 |
Echinococcus granulosus | uracil DNA glycosylase | 0.0075 | 0.3252 | 0.3252 |
Schistosoma mansoni | G/t mismatch-specific thymine DNA glycosylase | 0.0075 | 0.3252 | 0.3252 |
Chlamydia trachomatis | uracil DNA glycosylase | 0.0075 | 0.3252 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0044 | 0.1616 | 0.1616 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0347 | 0.0347 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0347 | 0.1067 |
Echinococcus multilocularis | uracil DNA glycosylase | 0.0075 | 0.3252 | 0.3252 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0074 | 0.317 | 0.317 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0347 | 0.1067 |
Brugia malayi | Uracil-DNA glycosylase | 0.0075 | 0.3252 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0347 | 0.0347 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0044 | 0.1616 | 0.1616 |
Loa Loa (eye worm) | uracil-DNA glycosylase | 0.0075 | 0.3252 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1497 | 0.4603 |
Toxoplasma gondii | uracil-DNA glycosylase | 0.0075 | 0.3252 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1497 | 0.4603 |
Plasmodium falciparum | uracil-DNA glycosylase | 0.0075 | 0.3252 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2488 | 0.7649 |
Plasmodium vivax | uracil-DNA glycosylase, putative | 0.0075 | 0.3252 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0075 | 0.3252 | 0.5 |
Mycobacterium leprae | PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG) | 0.0075 | 0.3252 | 0.5 |
Schistosoma mansoni | uracil-DNA glycosylase | 0.0075 | 0.3252 | 0.3252 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2488 | 0.7649 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0347 | 0.0347 |
Leishmania major | uracil-DNA-glycosylase, putative | 0.0075 | 0.3252 | 1 |
Mycobacterium ulcerans | uracil-DNA glycosylase | 0.0075 | 0.3252 | 1 |
Trypanosoma brucei | uracil-DNA glycosylase, putative | 0.0075 | 0.3252 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0347 | 0.0347 |
Trichomonas vaginalis | uracil DNA glycosylase, putative | 0.0075 | 0.3252 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0347 | 0.0347 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0074 | 0.317 | 0.317 |
Mycobacterium tuberculosis | Probable uracil DNA glycosylase, UdgB | 0.0075 | 0.3252 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.3252 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0074 | 0.317 | 0.317 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0347 | 0.0347 |
Trypanosoma cruzi | uracil-DNA glycosylase | 0.0075 | 0.3252 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2488 | 0.7649 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0347 | 0.1067 |
Brugia malayi | hypothetical protein | 0.0044 | 0.1616 | 0.4969 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0347 | 0.0347 |
Mycobacterium ulcerans | glycosylase | 0.0075 | 0.3252 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0044 | 0.1616 | 0.1616 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0347 | 0.1067 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2488 | 0.7649 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1497 | 0.1497 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0075 | 0.3252 | 1 |
Wolbachia endosymbiont of Brugia malayi | uracil-DNA glycosylase | 0.0075 | 0.3252 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0347 | 0.0347 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0074 | 0.317 | 0.317 |
Treponema pallidum | DNA polymerase | 0.0075 | 0.3252 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 244 nM | Viral Plaque Reduction Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.