Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.013 | 0.0046 | 0.0046 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.013 | 0.0046 | 0.0046 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.036 | 0.1136 | 0.1136 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.1411 | 0.3676 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0987 | 0.4114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 0.312 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.013 | 0.0046 | 0.0046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.