Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase 7A | 0.0622 | 0.7625 | 0.7625 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0622 | 0.7625 | 0.6473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0622 | 0.7625 | 0.6473 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0692 | 0.939 | 0.9094 |
Echinococcus granulosus | histone deacetylase 6 | 0.0622 | 0.7625 | 0.6473 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0692 | 0.939 | 0.9094 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0449 | 0.3267 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0449 | 0.3267 | 0.3267 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0622 | 0.7625 | 0.6473 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0622 | 0.7625 | 0.6473 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0449 | 0.3267 | 0.3267 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0449 | 0.3267 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.0622 | 0.7625 | 0.6473 |
Echinococcus multilocularis | histone deacetylase | 0.0622 | 0.7625 | 0.6473 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Brugia malayi | Histone deacetylase family protein | 0.0622 | 0.7625 | 0.6473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0449 | 0.3267 | 0.3267 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0449 | 0.3267 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0622 | 0.7625 | 0.6473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | histone deacetylase | 0.0622 | 0.7625 | 0.7625 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Brugia malayi | Histone deacetylase family protein | 0.0622 | 0.7625 | 0.6473 |
Echinococcus granulosus | histone deacetylase 6 | 0.0692 | 0.939 | 0.9094 |
Onchocerca volvulus | 0.0449 | 0.3267 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.1765 | 0.1765 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0449 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Echinococcus granulosus | histone deacetylase 7 | 0.0622 | 0.7625 | 0.6473 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3267 | 0.3267 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0622 | 0.7625 | 0.6473 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human thymidylate synthase A at 92 uM | ChEMBL. | 23273520 | |
Inhibition (binding) | Inhibition of Escherichia coli thymidylate synthase A at 92 uM | ChEMBL. | 23273520 | |
Ki (binding) | > 451 uM | Inhibition of Escherichia coli thymidylate synthase A | ChEMBL. | 23273520 |
Ki (binding) | > 474 uM | Inhibition of human thymidylate synthase A | ChEMBL. | 23273520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.