Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0425 | 0.3487 | 0.0283 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0408 | 0.3298 | 0.3055 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0425 | 0.3487 | 0.2634 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0855 | 0.816 | 0.816 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0425 | 0.3487 | 0.2634 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0425 | 0.3487 | 0.3487 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0408 | 0.3298 | 0.2419 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0425 | 0.3487 | 0.2634 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0855 | 0.816 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0855 | 0.816 | 0.7919 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.3298 | 0.3055 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0425 | 0.3487 | 0.0283 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0408 | 0.3298 | 0.2419 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0244 | 0.1519 | 0.0408 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0855 | 0.816 | 0.7254 |
Giardia lamblia | Kinase, CMGC CDK | 0.0425 | 0.3487 | 0.0283 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0458 | 0.3848 | 0.3841 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0855 | 0.816 | 0.7254 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0425 | 0.3487 | 0.3487 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0425 | 0.3487 | 0.2634 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0425 | 0.3487 | 0.2634 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0425 | 0.3487 | 0.2634 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0425 | 0.3487 | 0.3326 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0425 | 0.3487 | 0.0283 |
Brugia malayi | cell division control protein 2 homolog | 0.0425 | 0.3487 | 0.2634 |
Echinococcus multilocularis | dual specificity | 0.0408 | 0.3298 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.1003 | 0.9766 | 0.9736 |
Brugia malayi | Protein kinase domain containing protein | 0.0425 | 0.3487 | 0.2634 |
Echinococcus granulosus | dual specificity | 0.0408 | 0.3298 | 0.2419 |
Echinococcus granulosus | cyclin dependent kinase | 0.0425 | 0.3487 | 0.2634 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0425 | 0.3487 | 0.0283 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0425 | 0.3487 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 0.7926 | 0.7654 |
Echinococcus multilocularis | dual specificity | 0.0855 | 0.816 | 0.7919 |
Giardia lamblia | Kinase, CMGC CDK | 0.0425 | 0.3487 | 0.0283 |
Echinococcus multilocularis | dual specificity | 0.0408 | 0.3298 | 0.2419 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0425 | 0.3487 | 0.2634 |
Entamoeba histolytica | hypothetical protein | 0.0855 | 0.816 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0408 | 0.3298 | 0.3298 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 0.7926 | 0.7654 |
Echinococcus granulosus | dual specificity | 0.0408 | 0.3298 | 0.2419 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0425 | 0.3487 | 0.0283 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0425 | 0.3487 | 0.2634 |
Echinococcus granulosus | dual specificity | 0.0855 | 0.816 | 0.7919 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.3253 | 0.2369 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0855 | 0.816 | 0.7254 |
Echinococcus granulosus | dual specificity | 0.0408 | 0.3298 | 0.2419 |
Echinococcus granulosus | hypothetical protein | 0.1003 | 0.9766 | 0.9736 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0425 | 0.3487 | 0.0283 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0855 | 0.816 | 0.7919 |
Echinococcus multilocularis | dual specificity | 0.0408 | 0.3298 | 0.2419 |
Entamoeba histolytica | protein kinase, putative | 0.0855 | 0.816 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0855 | 0.816 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0425 | 0.3487 | 0.0283 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0244 | 0.1519 | 0.0408 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0425 | 0.3487 | 0.2634 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0425 | 0.3487 | 0.0283 |
Brugia malayi | Protein kinase domain containing protein | 0.0855 | 0.816 | 0.7919 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0425 | 0.3487 | 0.2634 |
Echinococcus multilocularis | 0.1003 | 0.9766 | 0.9736 | |
Echinococcus multilocularis | cyclin dependent kinase | 0.0425 | 0.3487 | 0.2634 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0425 | 0.3487 | 0.0283 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0425 | 0.3487 | 0.2634 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0408 | 0.3298 | 0.2419 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 111.6 % | Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis relative to Retro-2 | ChEMBL. | 23517565 |
EC50 (functional) | = 5.1 uM | Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis | ChEMBL. | 23517565 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23517565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.