TDR Targets

Basic information

Technical information

TDR Targets ID: 172741
Name: 2-morpholin-4-yl-6-phenylpyran-4-one
MW: 257.284 | Formula: C15H15NO3
H donors: 0 H acceptors: 1 LogP: 1.72 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(oc(c1)c1ccccc1)N1CCOCC1
InChi: 1S/C15H15NO3/c17-13-10-14(12-4-2-1-3-5-12)19-15(11-13)16-6-8-18-9-7-16/h1-5,10-11H,6-9H2
InChiKey: QQHMBGBSWORRAG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-morpholino-6-phenyl-pyran-4-one
2-morpholino-6-phenyl-4-pyranone
2-morpholin-4-yl-6-phenyl-pyran-4-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0016	0.0061	0.5
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0061	0.2238
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0271	0.0211
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Onchocerca volvulus		0.0016	0.0061	0.5
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Giardia lamblia	GTOR	0.0022	0.0271	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Leishmania major	hypothetical protein, conserved	0.0114	0.334	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0271	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0271	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0271	1
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.32	1
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0271	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Onchocerca volvulus		0.0016	0.0061	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0061	0.2238
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0271	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0271	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0061	0.2238
Onchocerca volvulus		0.0016	0.0061	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0271	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0016	0.0061	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0271	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0271	1
Onchocerca volvulus		0.0016	0.0061	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0271	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0061	0.2238

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.1 uM	In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells.	ChEMBL.	12941339
IC50 (binding)	= 1.1 uM	Inhibitory activity against DNA-dependent protein kinase receptor	ChEMBL.	16302822
IC50 (binding)	= 1.1 uM	In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells.	ChEMBL.	12941339
IC50 (binding)	= 1.1 uM	Inhibitory activity against DNA-dependent protein kinase receptor	ChEMBL.	16302822
IC50 (binding)	= 1.3 uM	Inhibition of DNA-PK in HeLa cell nuclear extracts	ChEMBL.	17371003
IC50 (binding)	= 1.3 uM	Inhibition of DNA-PK in HeLa cell nuclear extracts	ChEMBL.	17371003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL105613
PubChem: 10923175

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 172741