Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen-related receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | estrogen-related receptor beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen-related receptor beta | 508 aa | 461 aa | 25.2 % |
Brugia malayi | Steroid receptor seven-up type 2 | estrogen-related receptor alpha | 423 aa | 358 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.5 | 0.5 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 120.7 nM | Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysis | ChEMBL. | 23448346 |
IC50 (binding) | = 175.7 nM | Displacement of [3H]E2 from human recombinant ERalpha receptor after overnight incubation by liquid scintillation counting analysis | ChEMBL. | 23448346 |
RBA (binding) | = 3.4 % | Displacement of [3H]E2 from human recombinant ERalpha receptor after overnight incubation by liquid scintillation counting analysis relative to 17beta-estradiol | ChEMBL. | 23448346 |
RBA (binding) | = 7.2 % | Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysis relative to 17beta-estradiol | ChEMBL. | 23448346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.