Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0126 | 0.1836 | 0.1718 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0303 | 0.6589 | 0.6617 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0126 | 0.1836 | 0.0927 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0126 | 0.1836 | 0.5 |
Onchocerca volvulus | 0.0126 | 0.1836 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0428 | 0.9958 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0128 | 0.1878 | 0.156 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0126 | 0.1836 | 0.0927 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0126 | 0.1836 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0128 | 0.1878 | 0.0051 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0128 | 0.1878 | 0.1886 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0126 | 0.1836 | 0.1486 |
Schistosoma mansoni | protein kinase | 0.0303 | 0.6589 | 0.5822 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0128 | 0.1878 | 0.0973 |
Brugia malayi | Protein kinase domain containing protein | 0.0128 | 0.1878 | 0.1761 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1836 | 0.1718 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1836 | 0.1844 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.1878 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1836 | 0.1844 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0128 | 0.1878 | 0.0973 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.1878 | 0.0051 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0128 | 0.1878 | 0.0973 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0128 | 0.1878 | 0.156 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0126 | 0.1836 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0142 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.9958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1836 | 0.1844 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0128 | 0.1878 | 0.156 |
Echinococcus granulosus | protein kinase | 0.0303 | 0.6589 | 0.6237 |
Echinococcus multilocularis | 0.0303 | 0.6589 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 uM | Inhibition of human recombinant MMP1 catalytic domain using Dnp-Pro-beta-cyclohexyl-Ala-Gly-Cys(Me)-His-Lys-(Nma)-NH2 as substrate preincubated with enzyme for 30 mins prior to substrate addition measured after 20 mins by fluorometric assay | ChEMBL. | 23353736 |
Inhibition (binding) | = 100 % | Inhibition of human recombinant MMP1 catalytic domain using Dnp-Pro-beta-cyclohexyl-Ala-Gly-Cys(Me)-His-Lys-(Nma)-NH2 as substrate at 10 uM preincubated with enzyme for 30 mins prior to substrate addition measured after 20 mins by fluorometric assay | ChEMBL. | 23353736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.