Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0268 | 0.9878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.5433 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.9878 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0233 | 0.5433 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.5433 | 0.5501 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0233 | 0.5433 | 0.5501 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0233 | 0.5433 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0233 | 0.5433 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0233 | 0.5433 | 0.5501 |
Echinococcus multilocularis | laminin | 0.0233 | 0.5433 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0233 | 0.5433 | 0.5433 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.5433 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.5433 | 0.5501 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0233 | 0.5433 | 0.5501 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0233 | 0.5433 | 0.5433 |
Onchocerca volvulus | Arrow homolog | 0.0233 | 0.5433 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0233 | 0.5433 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0233 | 0.5433 | 1 |
Echinococcus granulosus | laminin | 0.0233 | 0.5433 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.5433 | 0.5501 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 11 uM | Growth inhibition of human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 23357037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.