Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | muscleblind protein 1 | 0.0152 | 0.1419 | 0.8663 |
Echinococcus granulosus | geminin | 0.0172 | 0.1638 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1419 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1419 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1638 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0152 | 0.1419 | 0.3367 |
Brugia malayi | DNA polymerase III, beta subunit | 0.0412 | 0.4214 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0152 | 0.1419 | 0.8663 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1638 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0152 | 0.1419 | 0.8663 |
Brugia malayi | DNA polymerase III, beta subunit | 0.0412 | 0.4214 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LC50 (functional) | = 7 uM | Cytotoxicity against HEK293 cells after 48 hrs by MTT assay | ChEMBL. | 23321564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.