Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | hydroxysteroid 11-beta dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid 11-beta dehydrogenase 1 | 292 aa | 246 aa | 25.2 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | microfilarial chitinase | 0.0237 | 0.0629 | 0.1641 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0387 | 0.383 | 0.5 |
Entamoeba histolytica | chitinase, putative | 0.0244 | 0.0768 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0273 | 0.1396 | 0.2052 |
Brugia malayi | Endochitinase | 0.0273 | 0.1396 | 0.2052 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0387 | 0.383 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0387 | 0.383 | 0.5 |
Brugia malayi | endochitinase | 0.0273 | 0.1396 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.383 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0273 | 0.1396 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.383 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0387 | 0.383 | 1 |
Onchocerca volvulus | 0.0387 | 0.383 | 1 | |
Onchocerca volvulus | 0.0387 | 0.383 | 1 | |
Loa Loa (eye worm) | cuticular endochitinase | 0.0244 | 0.0768 | 0.2004 |
Plasmodium vivax | hypothetical protein, conserved | 0.0387 | 0.383 | 0.5 |
Leishmania major | chitinase | 0.0244 | 0.0768 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0387 | 0.383 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0273 | 0.1396 | 0.2052 |
Loa Loa (eye worm) | chitinase I | 0.0244 | 0.0768 | 0.2004 |
Plasmodium falciparum | conserved protein, unknown function | 0.0387 | 0.383 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.1 nM | Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assay | ChEMBL. | 23414800 |
IC50 (binding) | > 100 nM | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assay | ChEMBL. | 23414800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.