Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.088 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.088 | 1 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.088 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.088 | 1 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.088 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.088 | 1 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.088 | 1 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.088 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.