Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.2071 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.2071 | 1 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.2071 | 1 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.2071 | 1 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.2071 | 1 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.2071 | 1 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.2071 | 1 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.2071 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MBC (functional) | = 200 ug ml-1 | Antimicrobial activity against Escherichia coli after 24 hrs by microdilution susceptibility test | ChEMBL. | 23318903 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.