Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0338 | 0.8386 | 0.8386 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0338 | 0.8386 | 0.8386 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0098 | 0.0897 | 0.0897 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0338 | 0.8386 | 0.8386 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 1 | 0.5 |
Onchocerca volvulus | 0.0389 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0369 | 0.9354 | 0.9354 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0098 | 0.0897 | 0.0897 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0369 | 0.9354 | 0.9354 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.6994 | 0.6994 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0338 | 0.8386 | 0.8386 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0185 | 0.3626 | 0.3626 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0315 | 0.7692 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0098 | 0.0897 | 0.0897 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0315 | 0.7692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0897 | 0.0897 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 94 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
Control (functional) | = 94 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
IC50 (binding) | = 6.5 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (binding) | = 0.32 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (binding) | = 0.32 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (functional) | = 1.2 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (functional) | = 1.2 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2231608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.