Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0167 | 0.6569 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0167 | 0.6569 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0167 | 0.6569 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.9776 | 0.9976 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0167 | 0.6569 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0167 | 0.6569 | 0.6569 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0065 | 0.2307 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0244 | 0.98 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0167 | 0.6569 | 0.6569 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0065 | 0.2307 | 0.2307 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0167 | 0.6569 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0244 | 0.98 | 0.98 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0167 | 0.6569 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0167 | 0.6569 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0065 | 0.2307 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0167 | 0.6569 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0167 | 0.6569 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0167 | 0.6569 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0167 | 0.6569 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0244 | 0.98 | 0.98 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0065 | 0.2307 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0167 | 0.6569 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0065 | 0.2307 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0167 | 0.6569 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0065 | 0.2307 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 51.1 % | Inhibition of [3H]5-HT reuptake at SERT in rat brain synaptosomes at 10 uM | ChEMBL. | 23394318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.