Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | DNA topoisomerase I | 0.0385 | 0.9777 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0385 | 0.9777 | 0.9777 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 1 | 1 |
Onchocerca volvulus | 0.0389 | 1 | 1 | |
Brugia malayi | brahma associated protein 60 kDa | 0.0385 | 0.9777 | 0.9777 |
Chlamydia trachomatis | SWIB complex protein | 0.0385 | 0.9777 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0385 | 0.9777 | 0.9777 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0385 | 0.9777 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.66 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (binding) | = 0.22 uM | Concentration required for in vitro inhibition of thymidylate synthase | ChEMBL. | 2231606 |
IC50 (binding) | = 0.22 uM | Concentration required for in vitro inhibition of thymidylate synthase | ChEMBL. | 2231606 |
IC50 (functional) | = 20 uM | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | ChEMBL. | 2231606 |
IC50 (functional) | = 20 uM | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | ChEMBL. | 2231606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.