Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Giardia lamblia | CDC72 | 0.1484 | 0.4814 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.2032 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.2032 | 1 | 1 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.1484 | 0.4814 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2032 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.2032 | 1 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2032 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2032 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.2032 | 1 | 1 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.1484 | 0.4814 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.1484 | 0.4814 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.1484 | 0.4814 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Agonist activity at CB1 receptor in mouse N1E-115 cells assessed as increase in ERK1/2 phosphorylation after 10 mins by Western blot analysis | ChEMBL. | 23357307 | |
Activity (binding) | Neutral antagonist activity at CB1 receptor in albino CD1 mouse vas deferens assessed as rightward shift in WIN 55,212-2 concentration response curve for electrically evoked contractions at 0.1 to 10 uM treated 20 mins before first addition of WIN 55,212-2 | ChEMBL. | 23357307 | |
Inhibition (binding) | Neutral antagonist activity at CB1 receptor in mouse N1E-115 cells assessed as inhibition of WIN 55,212-2-induced ERK1/2 phosphorylation at 1 uM treated 5 mins prior to WIN 55,212-2 challenge by Western blot analysis | ChEMBL. | 23357307 | |
Intrinsic activity (binding) | Intrinsic activity at CB1 receptor in albino CD1 mouse vas deferens assessed as increase in amplitude of electrically evoked contractions at 0.1 to 100 uM | ChEMBL. | 23357307 | |
Ki (binding) | = 287 nM | Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brain membrane without cerebellum by liquid scintillation counting analysis | ChEMBL. | 23357307 |
Ki (binding) | > 5000 nM | Displacement of [3H]CP55940 from CB2 receptor in CD1 mouse spleen membrane by liquid scintillation counting analysis | ChEMBL. | 23357307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.