TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.348 | Formula: C19H18F3NO
H donors: 1 H acceptors: 1 LogP: 3.25 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: FC(c1cccc(c1)CN1C2C3C4C1(O)C1C2C2C3CC4C12)(F)F
InChi: 1S/C19H18F3NO/c20-19(21,22)8-3-1-2-7(4-8)6-23-17-13-9-5-10-12-11(9)14(17)16(12)18(23,24)15(10)13/h1-4,9-17,24H,5-6H2
InChiKey: YRHTVCCWOBRDRR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Sigma-1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0396	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0995	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0995	1	1
Schistosoma mansoni	tensin-related	0.0599	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0995	1	1
Echinococcus granulosus	expressed conserved protein	0.0599	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0995	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0599	0.3382	0.3382
Schistosoma mansoni	tyrosine kinase	0.0995	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0995	1	1
Brugia malayi	SH2 domain containing protein	0.0995	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0396	0	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0599	0.3382	0.3382
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0995	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0995	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0599	0.3382	0.3382
Onchocerca volvulus		0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0995	1	1
Echinococcus multilocularis	SH2 motif	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Onchocerca volvulus		0.0995	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Brugia malayi	Variant SH3 domain containing protein	0.0599	0.3382	0.3382
Schistosoma mansoni	tyrosine kinase	0.0995	1	1
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0599	0.3382	0.3382
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0445	0.0805	0.0805
Giardia lamblia	Kinase, NEK	0.0396	0	0.5
Schistosoma mansoni	tensin-related	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Onchocerca volvulus		0.0995	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0396	0	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0599	0.3382	0.3382
Echinococcus granulosus	signal transduction protein lnk realted	0.0599	0.3382	0.3382
Schistosoma mansoni	signal transduction protein lnk-related	0.0599	0.3382	0.3382
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0995	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0995	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	TK/ABL protein kinase	0.0995	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0995	1	1
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Schistosoma mansoni	hypothetical protein	0.0599	0.3382	0.3382
Onchocerca volvulus		0.0599	0.3382	0.3382
Entamoeba histolytica	protein kinase, putative	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0396	0	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0599	0.3382	0.3382
Schistosoma mansoni	shc transforming protein	0.0599	0.3382	0.3382
Giardia lamblia	Kinase, NEK	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0995	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0995	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0396	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0995	1	1
Giardia lamblia	Protein 21.1	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0396	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0599	0.3382	0.3382
Schistosoma mansoni	growth factor receptor-bound protein	0.0599	0.3382	0.3382
Schistosoma mansoni	nck2/grb4	0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0995	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0599	0.3382	0.3382
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	CAMK family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0599	0.3382	0.3382
Echinococcus multilocularis	NCK adaptor protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0995	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0396	0	0.5
Onchocerca volvulus		0.0599	0.3382	0.3382
Onchocerca volvulus		0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0995	1	1
Onchocerca volvulus		0.0995	1	1
Toxoplasma gondii	protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0995	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0599	0.3382	0.3382
Schistosoma mansoni	GTPase activating protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Schistosoma mansoni	tensin	0.0599	0.3382	0.3382
Echinococcus multilocularis	SH2 motif	0.0599	0.3382	0.3382
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Schistosoma mansoni	SH2A	0.0599	0.3382	0.3382
Trichomonas vaginalis	TK family protein kinase	0.0396	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0396	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0396	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0445	0.0805	0.0805
Loa Loa (eye worm)	SRC-1	0.0995	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0995	1	1
Echinococcus granulosus	SH2 motif	0.0599	0.3382	0.3382
Echinococcus multilocularis	signal transduction protein lnk realted	0.0599	0.3382	0.3382
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0599	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	STE family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0599	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	NCK adaptor protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0995	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0599	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0995	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0995	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0599	0.3382	0.3382
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0396	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0995	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0995	1	1
Onchocerca volvulus		0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0599	0.3382	0.3382
Plasmodium falciparum	protein kinase, putative	0.0396	0	0.5
Brugia malayi	SH2 domain containing protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Onchocerca volvulus		0.0995	1	1
Echinococcus granulosus	tensin	0.0599	0.3382	0.3382
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0396	0	0.5
Schistosoma mansoni	vav2	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Toxoplasma gondii	STE kinase	0.0396	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0599	0.3382	0.3382
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0995	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0599	0.3382	0.3382
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0599	0.3382	0.3382
Loa Loa (eye worm)	STAT protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	tensin	0.0599	0.3382	0.3382
Echinococcus multilocularis	tensin	0.0599	0.3382	0.3382
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	0.0805	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0995	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0995	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0396	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0599	0.3382	0.3382
Echinococcus granulosus	SH2 motif	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0599	0.3382	0.3382
Onchocerca volvulus		0.0995	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	SH2 domain-containing protein	0.0599	0.3382	0.3382
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0599	0.3382	0.3382
Schistosoma mansoni	tyrosine kinase	0.0995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0599	0.3382	0.3382
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0599	0.3382	0.3382
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0599	0.3382	0.3382
Brugia malayi	protein-tyrosine kinase	0.0995	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0995	1	1
Schistosoma mansoni	tyrosine kinase	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Giardia lamblia	Kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0995	1	1
Schistosoma mansoni	tyrosine kinase	0.0995	1	1
Brugia malayi	Protein kinase domain containing protein	0.0995	1	1
Echinococcus multilocularis	N chimaerin	0.0599	0.3382	0.3382
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	0.0805	1
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Schistosoma mansoni	hypothetical protein	0.0599	0.3382	0.3382
Echinococcus granulosus	tyrosine protein kinase Blk	0.0995	1	1
Plasmodium vivax	protein kinase, putative	0.0396	0	0.5
Echinococcus granulosus	N chimaerin	0.0599	0.3382	0.3382
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0396	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0599	0.3382	0.3382
Brugia malayi	hypothetical protein	0.0995	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0995	1	1
Schistosoma mansoni	tyrosine kinase	0.0995	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0599	0.3382	0.3382
Brugia malayi	Variant SH3 domain containing protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	SH2 domain-containing protein	0.0599	0.3382	0.3382
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0599	0.3382	0.3382
Brugia malayi	Tensin	0.0599	0.3382	0.3382
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0995	1	1
Echinococcus granulosus	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0995	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0599	0.3382	0.3382
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0599	0.3382	0.3382
Leishmania major	C-8 sterol isomerase-like protein	0.0445	0.0805	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0995	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0995	1	1
Echinococcus multilocularis	tyrosine kinase	0.0995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0995	1	1
Brugia malayi	hypothetical protein	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0599	0.3382	0.3382
Onchocerca volvulus		0.0599	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Brugia malayi	SRC-1	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Brugia malayi	SH2 domain containing protein	0.0995	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Onchocerca volvulus		0.0599	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Echinococcus multilocularis	SH2 motif	0.0599	0.3382	0.3382
Echinococcus multilocularis		0.0599	0.3382	0.3382
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0995	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0995	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0396	0	0.5
Schistosoma mansoni	tensin	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0599	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Schistosoma mansoni	adapter molecule crk	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0599	0.3382	0.3382
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5
Schistosoma mansoni	tensin	0.0599	0.3382	0.3382
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0599	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0396	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.57	Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain	ChEMBL.	23414839
Ki (binding)	= 270 uM	Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain	ChEMBL.	23414839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2332497

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1733220