Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.242 | 0.2062 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0046 | 0.0524 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0052 | 0.0937 | 0.2183 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0052 | 0.0937 | 0.051 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0937 | 0.0437 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0937 | 0.2183 |
Echinococcus granulosus | cyclin B | 0.0071 | 0.242 | 0.2001 |
Echinococcus multilocularis | G1:S specific cyclin D1 | 0.0172 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Entamoeba histolytica | cyclin, putative | 0.0052 | 0.0937 | 0.2183 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0071 | 0.242 | 0.2001 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0071 | 0.242 | 0.2001 |
Leishmania major | cyclin | 0.0071 | 0.242 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0052 | 0.0937 | 0.0437 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Plasmodium vivax | protein kinase Crk2 | 0.0046 | 0.0524 | 0.5 |
Schistosoma mansoni | cyclins | 0.0052 | 0.0937 | 0.0437 |
Trichomonas vaginalis | cyclin B, putative | 0.0052 | 0.0937 | 0.2183 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0937 | 0.0437 |
Trichomonas vaginalis | cyclin A, putative | 0.0071 | 0.242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.242 | 0.2062 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0046 | 0.0524 | 0.0077 |
Trypanosoma cruzi | cyclin 6, putative | 0.0071 | 0.242 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0052 | 0.0937 | 0.0437 |
Echinococcus multilocularis | cyclin B3 1 | 0.0052 | 0.0937 | 0.0437 |
Trichomonas vaginalis | cyclin B3, putative | 0.0052 | 0.0937 | 0.2183 |
Echinococcus multilocularis | cyclin B | 0.0071 | 0.242 | 0.2001 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0071 | 0.242 | 1 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Giardia lamblia | Cyclin A | 0.0052 | 0.0937 | 0.2183 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0046 | 0.0524 | 0.0077 |
Trichomonas vaginalis | cyclin B, putative | 0.0071 | 0.242 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0071 | 0.242 | 1 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0937 | 0.0437 |
Trichomonas vaginalis | cyclins, putative | 0.0071 | 0.242 | 1 |
Onchocerca volvulus | 0.0071 | 0.242 | 0.5 | |
Trypanosoma brucei | mitotic cyclin 6 | 0.0071 | 0.242 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0071 | 0.242 | 1 |
Echinococcus granulosus | G1:S specific cyclin D1 | 0.0172 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0052 | 0.0937 | 0.2183 |
Trichomonas vaginalis | cyclin B, putative | 0.0071 | 0.242 | 1 |
Plasmodium falciparum | cyclin | 0.0052 | 0.0937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.0071 | 0.242 | 0.2001 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.0937 | 0.2183 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0046 | 0.0524 | 0.0077 |
Trichomonas vaginalis | cyclin D, putative | 0.0052 | 0.0937 | 0.2183 |
Schistosoma mansoni | cyclin d | 0.0172 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0052 | 0.0937 | 0.2183 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0071 | 0.242 | 1 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.9063 | 0.9018 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0052 | 0.0937 | 0.0437 |
Entamoeba histolytica | cyclin family protein | 0.0052 | 0.0937 | 0.2183 |
Echinococcus multilocularis | cyclin b3 | 0.0052 | 0.0937 | 0.0437 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0071 | 0.242 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0071 | 0.242 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0071 | 0.242 | 1 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Trichomonas vaginalis | cyclins, putative | 0.0071 | 0.242 | 1 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0937 | 0.0437 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0937 | 0.0437 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0052 | 0.0937 | 0.0437 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0937 | 0.0437 |
Trypanosoma cruzi | cyclin, putative | 0.0071 | 0.242 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0071 | 0.242 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0071 | 0.242 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0052 | 0.0937 | 0.0437 |
Schistosoma mansoni | cyclin B3 | 0.0052 | 0.0937 | 0.0437 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cp(f) (ADMET) | = 9.4 % | Fraction unbound in human plasma by LC-MS/MS analysis | ChEMBL. | 23398453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.