Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | Starlite/ChEMBL | References |
Homo sapiens | discoidin domain receptor tyrosine kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | discoidin domain receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130314 | All targets in OG5_130314 |
Echinococcus granulosus | discoidin domain receptor | Get druggable targets OG5_130314 | All targets in OG5_130314 |
Loa Loa (eye worm) | TK/DDR protein kinase | Get druggable targets OG5_130314 | All targets in OG5_130314 |
Onchocerca volvulus | Get druggable targets OG5_130314 | All targets in OG5_130314 | |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130314 | All targets in OG5_130314 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130314 | All targets in OG5_130314 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | Get druggable targets OG5_132967 | All targets in OG5_132967 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | casein kinase II, putative | 0.0684 | 0.4133 | 0.5 |
Echinococcus granulosus | single minded 2 | 0.0126 | 0.0572 | 0.0572 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0684 | 0.4133 | 0.5 |
Brugia malayi | Casein kinase II, alpha chain | 0.0684 | 0.4133 | 0.3777 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Plasmodium vivax | unspecified product | 0.0684 | 0.4133 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0684 | 0.4133 | 0.3777 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1602 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0684 | 0.4133 | 0.3777 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.067 | 0.4046 | 0.4046 |
Echinococcus granulosus | discoidin domain receptor | 0.0265 | 0.1458 | 0.1458 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0684 | 0.4133 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0268 | 0.148 | 0.0963 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1602 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1602 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.127 | 0.7878 | 0.775 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1602 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0126 | 0.0572 | 0.0572 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0684 | 0.4133 | 1 |
Onchocerca volvulus | 0.127 | 0.7878 | 0.751 | |
Loa Loa (eye worm) | TK/DDR protein kinase | 0.0235 | 0.1268 | 0.0738 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0684 | 0.4133 | 0.3777 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0684 | 0.4133 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0684 | 0.4133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.1268 | 0.0738 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1602 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0684 | 0.4133 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0684 | 0.4133 | 0.4133 |
Entamoeba histolytica | casein kinase, putative | 0.0684 | 0.4133 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0126 | 0.0572 | 0.0572 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1602 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0684 | 0.4133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.1458 | 0.094 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0684 | 0.4133 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1602 | 1 | 1 |
Mycobacterium leprae | Possible transporter protein | 0.0126 | 0.0572 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8320 nM | Inhibition of c-KIT (unknown origin) using Ser/Thr 6 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET assay | ChEMBL. | 23521020 |
IC50 (binding) | > 1 uM | Inhibition of DDR2 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by TR-FRET assay | ChEMBL. | 23521020 |
IC50 (binding) | > 1 uM | Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 hr by TR-FRET assay | ChEMBL. | 23521020 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.