Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 1 | 1 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0033 | 0.1164 | 0.1164 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.011 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.011 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.011 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.011 | 1 | 1 |
Treponema pallidum | pyruvate phosphate dikinase | 0.0046 | 0.263 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.011 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.011 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0077 | 0.6166 | 0.6166 |
Echinococcus multilocularis | pyruvate kinase | 0.011 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0077 | 0.6166 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.011 | 1 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.011 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.011 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.011 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.011 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.011 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | pyruvate phosphate dikinase | 0.0046 | 0.263 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.011 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.011 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.011 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.011 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.011 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0057 | 0.3834 | 0.1633 |
Trypanosoma brucei | pyruvate kinase 1 | 0.011 | 1 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.011 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.011 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.011 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.6166 | 0.6166 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.011 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0087 | 0.7331 | 0.5671 |
Echinococcus granulosus | pyruvate kinase | 0.011 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.03 uM | Transactivation of GAL4 DBD-fused human PPARgamma-LBD expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23294830 |
Efficacy (binding) | = 18 % | Transactivation of GAL4 DBD-fused human PPARgamma-LBD expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay relative to rosiglitazone | ChEMBL. | 23294830 |
IC50 (binding) | = 0.05 uM | Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assay | ChEMBL. | 23294830 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.