TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.464 | Formula: C20H21N3O3S
H donors: 2 H acceptors: 4 LogP: 3.27 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(Nc1c(cnc2c1ccc(c2)c1ccc(cc1)S(=O)(=O)C)C(=O)N)C
InChi: 1S/C20H21N3O3S/c1-12(2)23-19-16-9-6-14(10-18(16)22-11-17(19)20(21)24)13-4-7-15(8-5-13)27(3,25)26/h4-12H,1-3H3,(H2,21,24)(H,22,23)
InChiKey: JZGUOMOIPAOOAG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leucine-rich repeat kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TKL/LRRK protein kinase	Get druggable targets OG5_131478	All targets in OG5_131478
Echinococcus granulosus	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131478	All targets in OG5_131478
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	growth factor receptor bound protein 2	0.0119	0.259	0.2571
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0135	0.3462	0.0954
Echinococcus multilocularis	tensin	0.0119	0.259	0.259
Echinococcus granulosus	tensin	0.0119	0.259	0.2571
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0257	1	1
Brugia malayi	Raf kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Schistosoma mansoni	protein kinase	0.0073	0.012	0.001
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0072	0.011	0.011
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0119	0.259	0.2507
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0073	0.012	0.012
Onchocerca volvulus		0.0119	0.259	0.3901
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0072	0.011	0.011
Brugia malayi	Tensin	0.0119	0.259	0.259
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0119	0.259	0.259
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0072	0.011	0.011
Echinococcus multilocularis	epidermal growth factor receptor	0.0072	0.011	0.011
Echinococcus granulosus	activated cdc42 kinase 1	0.0072	0.011	0.0085
Schistosoma mansoni	nck2/grb4	0.0119	0.259	0.2507
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0191	0.6467	0.6458
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0072	0.011	0.011
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0119	0.259	0.259
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0119	0.259	0.259
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0119	0.259	0.2571
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0191	0.6467	0.6467
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0119	0.259	0.259
Schistosoma mansoni	suppressor of cytokine signaling	0.0119	0.259	0.2507
Loa Loa (eye worm)	TK/DDR protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0072	0.011	0.011
Entamoeba histolytica	protein kinase domain containing protein	0.0073	0.012	0.0016
Echinococcus granulosus	tyrosine protein kinase Srms	0.0191	0.6467	0.6458
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0191	0.6467	0.6467
Schistosoma mansoni	tyrosine kinase	0.0191	0.6467	0.6427
Brugia malayi	Guanylyl cyclase protein 23	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0072	0.011	0.011
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	expressed conserved protein	0.0119	0.259	0.2571
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Echinococcus granulosus	tyrosine protein kinase pr2	0.0072	0.011	0.0085
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.0141	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0257	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0119	0.259	0.2507
Schistosoma mansoni	tensin-related	0.0119	0.259	0.2507
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Echinococcus granulosus	insulin receptor	0.0072	0.011	0.0085
Echinococcus multilocularis	protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase csk	0.0072	0.011	0.011
Echinococcus multilocularis	heat shock protein 70	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0191	0.6467	0.6467
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0072	0.011	0.0085
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Blk	0.0191	0.6467	0.6458
Brugia malayi	Variant SH3 domain containing protein	0.0119	0.259	0.259
Loa Loa (eye worm)	SRC-1	0.0191	0.6467	0.6467
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0257	1	1
Schistosoma mansoni	vav2	0.0119	0.259	0.2507
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0191	0.6467	0.6458
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0191	0.6467	0.6458
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Onchocerca volvulus		0.0191	0.6467	1
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0191	0.6467	0.6467
Schistosoma mansoni	growth factor receptor-bound protein	0.0119	0.259	0.2507
Schistosoma mansoni	tensin	0.0119	0.259	0.2507
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0191	0.6477	0.6468
Echinococcus granulosus	N chimaerin	0.0119	0.259	0.2571
Entamoeba histolytica	hypothetical protein	0.0073	0.0141	0.0048
Echinococcus granulosus	natriuretic peptide receptor 1	0.0072	0.011	0.0085
Schistosoma mansoni	SH2A	0.0119	0.259	0.2507
Echinococcus granulosus	SH2 motif	0.0119	0.259	0.2571
Echinococcus granulosus	ephrin type A receptor 4 A	0.0072	0.011	0.0085
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Entamoeba histolytica	protein kinase, putative	0.0072	0.0116	0.0008
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Echinococcus granulosus	activated cdc42 kinase 1	0.0072	0.011	0.0085
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0119	0.259	0.259
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0072	0.011	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Echinococcus granulosus	SH2 domain containing protein 7	0.0119	0.259	0.2571
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0257	1	1
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0257	1	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0072	0.011	0.011
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0072	0.011	0.011
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0073	0.012	0.0095
Brugia malayi	Protein kinase domain containing protein	0.0191	0.6467	0.6467
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0257	1	1
Schistosoma mansoni	tyrosine kinase	0.0191	0.6467	0.6427
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0119	0.259	0.2571
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	integrin linked protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine kinase	0.0191	0.6467	0.6458
Echinococcus multilocularis	SHC transforming protein 3	0.0119	0.259	0.259
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0072	0.011	0.011
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0119	0.259	0.2571
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0191	0.6467	0.6467
Echinococcus multilocularis	protein tyrosine kinase	0.0072	0.011	0.011
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0072	0.011	0.011
Onchocerca volvulus		0.0191	0.6467	1
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0119	0.259	0.259
Brugia malayi	Protein kinase domain containing protein	0.0191	0.6467	0.6467
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0257	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Schistosoma mansoni	tensin	0.0119	0.259	0.2507
Trypanosoma cruzi	GMP reductase	0.0257	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	integrin linked protein kinase	0.0072	0.011	0.0085
Schistosoma mansoni	suppressor of cytokine signaling	0.0119	0.259	0.2507
Echinococcus granulosus	epidermal growth factor receptor	0.0072	0.011	0.0085
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0119	0.259	0.2571
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0119	0.259	0.259
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0072	0.011	0.0085
Schistosoma mansoni	tyrosine kinase	0.0191	0.6467	0.6427
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0072	0.011	0.011
Schistosoma mansoni	shc transforming protein	0.0119	0.259	0.2507
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0191	0.6467	0.6458
Loa Loa (eye worm)	TK/INSR protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	SH2 domain-containing protein	0.0119	0.259	0.259
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Loa Loa (eye worm)	TK/RYK protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0119	0.259	0.259
Echinococcus multilocularis	activated cdc42 kinase 1	0.0072	0.011	0.011
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0072	0.011	0.0085
Loa Loa (eye worm)	TK/ALK protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	hypothetical protein	0.0119	0.259	0.2571
Brugia malayi	RhoGAP domain containing protein	0.0119	0.259	0.259
Schistosoma mansoni	signal transduction protein lnk-related	0.0119	0.259	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0242	0.9183	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0072	0.011	0.0085
Trypanosoma brucei	protein kinase, putative	0.0073	0.012	0.001
Echinococcus granulosus	tyrosine protein kinase HCK	0.0072	0.011	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Entamoeba histolytica	hypothetical protein	0.0072	0.0116	0.0008
Echinococcus multilocularis	transfer RNA-Thr	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.011	0.011
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Entamoeba histolytica	SH2 domain containing protein	0.0119	0.259	0.3901
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase csk	0.0072	0.011	0.0085
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0072	0.011	0.0085
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Loa Loa (eye worm)	STAT protein	0.0119	0.259	0.259
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0119	0.259	0.259
Schistosoma mansoni	GTPase activating protein	0.0119	0.259	0.2507
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	serine/threonine protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Brugia malayi	hypothetical protein	0.0191	0.6467	0.6467
Echinococcus granulosus	epidermal growth factor receptor	0.0072	0.011	0.0085
Brugia malayi	SH2 domain containing protein	0.0191	0.6467	0.6467
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0072	0.011	0.0085
Toxoplasma gondii	IMP dehydrogenas	0.0257	1	1
Onchocerca volvulus		0.0119	0.259	0.3901
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0072	0.011	0.011
Schistosoma mansoni	tyrosine kinase	0.0191	0.6467	0.6427
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0072	0.011	0.0085
Giardia lamblia	Kinase, NEK	0.0072	0.011	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0072	0.011	0.011
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase	0.0072	0.011	0.011
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0242	0.9183	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0191	0.6467	0.6467
Loa Loa (eye worm)	SH2 domain-containing protein	0.0119	0.259	0.259
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0257	1	1
Brugia malayi	hypothetical protein	0.0072	0.011	0.011
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0119	0.259	0.259
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Trypanosoma brucei	GMP reductase	0.0257	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0119	0.259	0.259
Brugia malayi	GMP reductase	0.0107	0.1955	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0119	0.259	0.3901
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0072	0.011	0.011
Echinococcus granulosus	NCK adaptor protein	0.0119	0.259	0.2571
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.011	0.011
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0257	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0072	0.011	0.011
Giardia lamblia	Kinase, NEK	0.0072	0.011	0.5
Echinococcus granulosus	protein kinase	0.0072	0.011	0.0085
Loa Loa (eye worm)	GMP reductase	0.0107	0.1955	0.1955
Schistosoma mansoni	growth factor receptor-bound protein	0.0119	0.259	0.2507
Echinococcus multilocularis	insulin receptor	0.0072	0.011	0.011
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0073	0.012	0.001
Schistosoma mansoni	protein kinase	0.0073	0.012	0.001
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0191	0.6467	0.6458
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0072	0.011	0.0085
Brugia malayi	Sex muscle abnormal protein 5	0.0119	0.259	0.259
Echinococcus multilocularis	SH2 motif	0.0119	0.259	0.259
Echinococcus granulosus	activin receptor type	0.0073	0.012	0.0095
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Echinococcus granulosus	receptor type guanylyl cyclase	0.0072	0.011	0.0085
Brugia malayi	Tyrosine-protein kinase abl-1	0.0191	0.6467	0.6467
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0257	1	1
Echinococcus granulosus	protein tyrosine kinase	0.0072	0.011	0.0085
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Brugia malayi	hypothetical protein	0.0119	0.259	0.259
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0119	0.259	0.2571
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0072	0.011	0.0085
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0119	0.259	0.259
Echinococcus granulosus	raf serine:threonine protein kinase	0.0072	0.011	0.0085
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0119	0.259	0.259
Echinococcus granulosus	c src tyrosine kinase	0.0191	0.6467	0.6458
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Brugia malayi	Variant SH3 domain containing protein	0.0119	0.259	0.259
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0191	0.6467	0.6458
Echinococcus granulosus	tyrosine protein kinase	0.0072	0.011	0.0085
Schistosoma mansoni	tensin-related	0.0119	0.259	0.2507
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0073	0.012	0.001
Echinococcus multilocularis	activin receptor type	0.0073	0.012	0.012
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0257	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0119	0.259	0.2571
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0191	0.6467	0.6467
Brugia malayi	C-terminal src kinase protein 1	0.0072	0.011	0.011
Onchocerca volvulus		0.0119	0.259	0.3901
Brugia malayi	SH2 domain containing protein	0.0119	0.259	0.259
Echinococcus granulosus	tyrosine protein kinase csk	0.0072	0.011	0.0085
Echinococcus granulosus	tyrosine protein kinase shark	0.0191	0.6467	0.6458
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0191	0.6467	0.6427
Echinococcus multilocularis	signal transduction protein lnk realted	0.0119	0.259	0.259
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0191	0.6467	0.6458
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Loa Loa (eye worm)	SH2 domain-containing protein	0.0119	0.259	0.259
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0073	0.012	0.001
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0119	0.259	0.2507
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0119	0.259	0.2571
Schistosoma mansoni	protein kinase	0.0073	0.012	0.001
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0072	0.011	0.0085
Echinococcus granulosus	tyrosine kinase	0.0191	0.6467	0.6458
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0072	0.011	0.0085
Brugia malayi	Variant SH3 domain containing protein	0.0119	0.259	0.259
Schistosoma mansoni	hypothetical protein	0.0119	0.259	0.2507
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0191	0.6467	0.6467
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/EPH protein kinase	0.0072	0.011	0.011
Trypanosoma cruzi	GMP reductase	0.0257	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0072	0.011	0.011
Onchocerca volvulus	Putative GMP reductase	0.0107	0.1955	0.2901
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0072	0.011	0.011
Brugia malayi	SRC-1	0.0191	0.6467	0.6467
Brugia malayi	integrin-linked kinase	0.0072	0.011	0.011
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0072	0.011	0.011
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0072	0.011	0.011
Brugia malayi	protein-tyrosine kinase	0.0191	0.6467	0.6467
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0119	0.259	0.259
Echinococcus multilocularis	protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0119	0.259	0.259
Onchocerca volvulus		0.0191	0.6467	1
Leishmania major	protein kinase, putative	0.0073	0.012	0.001
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0257	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0119	0.259	0.2571
Brugia malayi	Furin-like cysteine rich region family protein	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine kinase	0.0072	0.011	0.011
Entamoeba histolytica	hypothetical protein	0.0072	0.0116	0.0008
Loa Loa (eye worm)	TK protein kinase	0.0191	0.6467	0.6467
Entamoeba histolytica	protein kinase, putative	0.0119	0.26	0.3917
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0191	0.6467	0.6458
Echinococcus multilocularis	c src tyrosine kinase	0.0191	0.6467	0.6467
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0072	0.011	0.0085
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0191	0.6467	0.6467
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0191	0.6467	0.6467
Onchocerca volvulus		0.0191	0.6467	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/ABL protein kinase	0.0191	0.6467	0.6467
Brugia malayi	Tyrosine-protein kinase PR2	0.0072	0.011	0.011
Onchocerca volvulus		0.0191	0.6467	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Echinococcus multilocularis	tyrosine protein kinase csk	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0119	0.259	0.2507
Brugia malayi	Protein kinase domain containing protein	0.0191	0.6467	0.6467
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0191	0.6467	0.6467
Loa Loa (eye worm)	TK/CSK protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0072	0.011	0.0085
Plasmodium falciparum	protein kinase, putative	0.0073	0.012	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0119	0.259	0.3901
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0072	0.011	0.011
Echinococcus granulosus	SHC transforming protein 3	0.0119	0.259	0.2571
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0119	0.259	0.259
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0242	0.9183	0.8869
Giardia lamblia	Kinase	0.0072	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Brugia malayi	Receptor family ligand binding region containing protein	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine kinase	0.0072	0.011	0.0085
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0073	0.012	0.001
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0191	0.6467	0.6467
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus multilocularis	tensin	0.0119	0.259	0.259
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0191	0.6467	0.6458
Echinococcus granulosus	tyrosine protein kinase csk	0.0072	0.011	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Onchocerca volvulus		0.0119	0.259	0.3901
Schistosoma mansoni	tyrosine kinase	0.0191	0.6467	0.6427
Schistosoma mansoni	hypothetical protein	0.0119	0.259	0.2507
Echinococcus multilocularis	SH2 motif	0.0119	0.259	0.259
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0191	0.6467	0.6467
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0072	0.011	0.011
Brugia malayi	hypothetical protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0072	0.011	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0119	0.259	0.259
Echinococcus multilocularis	tyrosine protein kinase shark	0.0191	0.6467	0.6467
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0191	0.6467	0.6467
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0191	0.6467	0.6458
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0191	0.6467	0.6467
Echinococcus multilocularis	SH2 domain containing protein 7	0.0119	0.259	0.259
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0107	0.1955	0.1955
Loa Loa (eye worm)	TK/ROR protein kinase	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0191	0.6467	0.6467
Echinococcus multilocularis	tyrosine protein kinase csk	0.0072	0.011	0.011
Entamoeba histolytica	hypothetical protein	0.0072	0.0116	0.0008
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0119	0.259	0.2507
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0072	0.011	0.011
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0119	0.26	0.3917
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0072	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0191	0.6467	0.6458
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Brugia malayi	ephrin receptor 1 precursor	0.0072	0.011	0.011
Giardia lamblia	Protein 21.1	0.0072	0.011	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0119	0.259	0.2571
Loa Loa (eye worm)	TK protein kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0072	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0191	0.6467	0.6467
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0257	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0119	0.259	0.259
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0191	0.6467	0.6467
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0119	0.259	0.2571
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0119	0.259	0.259
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0191	0.6467	1
Echinococcus multilocularis	FL cytokine receptor	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Onchocerca volvulus		0.0191	0.6467	1
Echinococcus multilocularis	tyrosine kinase	0.0191	0.6467	0.6467
Leishmania major	guanosine monophosphate reductase	0.0257	1	1
Echinococcus multilocularis		0.0119	0.259	0.259
Schistosoma mansoni	adapter molecule crk	0.0119	0.259	0.2507
Brugia malayi	Protein kinase domain containing protein	0.0072	0.011	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0119	0.259	0.259
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0072	0.011	0.011
Echinococcus multilocularis	SH2 motif	0.0119	0.259	0.259
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0119	0.259	0.259
Loa Loa (eye worm)	TK/FER protein kinase	0.0191	0.6467	0.6467
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0072	0.011	0.011
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0072	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.011	0.011
Echinococcus granulosus	SH2 motif	0.0119	0.259	0.2571
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0107	0.1955	0.1955
Onchocerca volvulus		0.0119	0.259	0.3901
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0072	0.011	0.0085
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0072	0.0116	0.0008
Schistosoma mansoni	tyrosine kinase	0.0191	0.6467	0.6427
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0119	0.259	0.259
Onchocerca volvulus		0.0119	0.259	0.3901
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0072	0.011	0.011
Brugia malayi	SH2 domain containing protein	0.0191	0.6467	0.6467
Loa Loa (eye worm)	TK/FAK protein kinase	0.0072	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0191	0.6467	0.6467
Schistosoma mansoni	tensin	0.0119	0.259	0.2507
Echinococcus multilocularis	NCK adaptor protein	0.0119	0.259	0.259
Echinococcus multilocularis	N chimaerin	0.0119	0.259	0.259
Echinococcus granulosus	kinase suppressor of Ras 1	0.0072	0.011	0.0085
Echinococcus multilocularis	tyrosine protein kinase csk	0.0072	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0072	0.011	0.011

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 35 nM	Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphorylation by HTRF assay in presence of ATP	ChEMBL.	23219325
IC50 (binding)	= 0.039 uM	Inhibition of wild type GST-tagged LRRK2 (970-2527 amino acids)(unknown origin) assessed as inhibition of LRRKtide phosphorylation by HTRF assay	ChEMBL.	23453068
IC50 (binding)	= 0.041 uM	Inhibition of GST-tagged LRRK2 G2019S mutant (970-2527 amino acids) (unknown origin) assessed as inhibition of LRRKtide phosphorylation by HTRF assay	ChEMBL.	23453068
Inhibition (binding)	= -2 %	Inhibition of PIK3CA/PIK3R1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 0 %	Inhibition of CAMK2alpha (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 1 %	Inhibition of PLK3 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 1 %	Inhibition of PLK1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 1 %	Inhibition of CDK1/cyclin B (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 2 %	Inhibition of CLK1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 2 %	Inhibition of CDK5/P25 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 4 %	Inhibition of MAPK10 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 4 %	Inhibition of INSR (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 5 %	Inhibition of CDK2/cyclin A (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 5 %	Inhibition of AKT1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 6 %	Inhibition of PRKACA (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 6 %	Inhibition of GSK3beta (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 7 %	Inhibition of PLK2 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 7 %	Inhibition of MAPK1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 8 %	Inhibition of PRKCbeta1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 9 %	Inhibition of DYRK1B (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 11 %	Inhibition of ERBB4 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 14 %	Inhibition of IRAK4 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 17 %	Inhibition of RAF1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 31 %	Inhibition of LCK (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 39 %	Inhibition of STK16 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 47 %	Inhibition of FAK2 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 50 %	Inhibition of TTK (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 50 %	Inhibition of ABL1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 52 %	Inhibition of RIPK2 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 60 %	Inhibition of Aurora A (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 64 %	Inhibition of PAK4 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 72 %	Inhibition of SYK (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 72 %	Inhibition of CHK1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 73 %	Inhibition of RET (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 75 %	Inhibition of FLT3 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 77 %	Inhibition of JAK1 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 86 %	Inhibition of ROCK2 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 89 %	Inhibition of MAP3K7 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 94 %	Inhibition of MARK2 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 96 %	Inhibition of LRRK2 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 98 %	Inhibition of PDGFRalpha (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 98 %	Inhibition of CSF1R (unknown origin) at 10 uM relative to control	ChEMBL.	23219325
Inhibition (binding)	= 100 %	Inhibition of STK3 (unknown origin) at 10 uM relative to control	ChEMBL.	23219325

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333125

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1735400