Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, T type, alpha 1G subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.4584 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0565 | 0.9326 | 0.9122 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0565 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0596 | 1 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0357 | 0.4742 | 0.5 |
Brugia malayi | valosin containing protein | 0.035 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0565 | 0.9326 | 1 |
Giardia lamblia | AAA family ATPase | 0.0357 | 0.4742 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0565 | 0.9326 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0565 | 0.9326 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0565 | 0.9326 | 0.5 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0246 | 0.232 | 0.2386 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0357 | 0.4742 | 0.0000097958 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.035 | 0.4584 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0596 | 1 | 1 |
Mycobacterium ulcerans | ATPase | 0.0357 | 0.4742 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0565 | 0.9326 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.1481 | 0.1481 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0596 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.035 | 0.4584 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0246 | 0.232 | 0.2386 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0565 | 0.9326 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0596 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.23 uM | Inhibition of alpha-1G calcium channel in human HEK293 cells by whole-cell patch-clamp method | ChEMBL. | 23395659 |
Inhibition (binding) | = 56.57 % | Inhibition of alpha-1G calcium channel in human HEK293 cells at 10 uM by whole-cell patch-clamp method | ChEMBL. | 23395659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.