Detailed information for compound 1735986

Basic information

Technical information
  • TDR Targets ID: 1735986
  • Name: [(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylox an-2-yl] 4-hydroxybenzoate
  • MW: 284.262 | Formula: C13H16O7
  • H donors: 4 H acceptors: 5 LogP: -0.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1[C@@H](O[C@H]([C@@H]([C@H]1O)O)C)OC(=O)c1ccc(cc1)O
  • InChi: 1S/C13H16O7/c1-6-9(15)10(16)11(17)13(19-6)20-12(18)7-2-4-8(14)5-3-7/h2-6,9-11,13-17H,1H3/t6-,9-,10+,11+,13-/m0/s1
  • InChiKey: GDBUPEWJRQHTCI-PGRGYFNBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl] 4-hydroxybenzoate
  • 4-hydroxybenzoic acid [(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-tetrahydropyranyl] ester
  • 4-hydroxybenzoic acid [(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl] ester
  • [(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl] 4-hydroxybenzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0132 0.0065 0.0065
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0114 0.0052 0.0052
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.0318 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Onchocerca volvulus 0.0132 0.0065 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0079 0.0028 0.0028
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0132 0.0065 0.0065
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0114 0.0052 0.0028
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.0065 0.0041
Echinococcus granulosus g protein coupled receptor 0.0132 0.0065 0.0041
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0132 0.0065 0.0065
Brugia malayi Dopamine receptor protein 2 0.0132 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus granulosus orexin receptor type 2 0.0132 0.0065 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.0065 0.0041
Schistosoma mansoni hypothetical protein 0.0132 0.0065 0.0065
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus multilocularis G protein coupled receptor 139 0.0132 0.0065 0.0065
Schistosoma mansoni neuropeptide receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.0065 0.0065
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0114 0.0052 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.0065 0.0065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0132 0.0065 0.0041
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0132 0.0065 0.0063
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 1.4439 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.0065 0.0041
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.0065 0.0063
Echinococcus granulosus survival motor neuron protein 1 0.0187 0.0103 0.0079
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0074 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus tachykinin peptides receptor 99D 0.0132 0.0065 0.0041
Echinococcus granulosus dro:myosuppressin receptor 0.0132 0.0065 0.0041
Brugia malayi Niemann-Pick C1 protein precursor 0.0078 0.0028 0.0028
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0132 0.0065 0.0063
Brugia malayi neuropeptide F receptor 0.0132 0.0065 0.0065
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0132 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis neuropeptide FF receptor 2 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0132 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0103 0.0101
Echinococcus granulosus neuropeptide s receptor 0.0496 0.0318 0.0294
Brugia malayi Melatonin receptor type 1A 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni neuropeptide f receptor 76f 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus serotonin receptor 0.0132 0.0065 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Brugia malayi G-protein coupled receptor 0.0132 0.0065 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.0065 0.0041
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0132 0.0065 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.0065 0.0041
Schistosoma mansoni opsin-like receptor 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni opsin-like receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) TYRA-2 protein 0.0132 0.0065 0.0063
Echinococcus granulosus allatostatin A receptor 0.0132 0.0065 0.0041
Echinococcus multilocularis fmrfamide receptor 0.0132 0.0065 0.0065
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.0065 0.0065
Echinococcus granulosus sex peptide receptor 0.0132 0.0065 0.0041
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0074 0.0025 0.4744
Schistosoma mansoni biogenic amine receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus multilocularis serotonin receptor 0.0254 0.015 0.015
Echinococcus multilocularis g protein coupled receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni biogenic amine receptor 0.0132 0.0065 0.0065
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0132 0.0065 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0132 0.0065 0.0065
Echinococcus multilocularis survival motor neuron protein 1 0.0187 0.0103 0.0103
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.0065 0.0065
Echinococcus granulosus g-protein coupled receptor 0.0132 0.0065 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Brugia malayi G-protein coupled receptor 0.0132 0.0065 0.0065
Brugia malayi RE15519p 0.0132 0.0065 0.0065
Echinococcus granulosus 7TM GPCR rhodopsin 0.0132 0.0065 0.0041
Schistosoma mansoni alpha-1 adrenergic receptor 0.0132 0.0065 0.0065
Echinococcus granulosus Niemann Pick C1 protein 0.0078 0.0028 0.0003
Echinococcus granulosus neuropeptide receptor 0.0132 0.0065 0.0041
Echinococcus granulosus biogenic amine 5HT receptor 0.0254 0.015 0.0126
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.0318 0.0318
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.0065 0.0041
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0132 0.0065 0.0065
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 1.4439 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus granulosus peptidase Clp S14 family 0.0074 0.0025 0.0001
Schistosoma mansoni peptidase Clp (S14 family) 0.0114 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Onchocerca volvulus 0.0132 0.0065 1
Brugia malayi larval opioid receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Schistosoma mansoni biogenic amine (5HT) receptor 0.0254 0.015 0.015
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.0065 0.0065
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0132 0.0065 0.0065
Brugia malayi Probable ClpP-like protease 0.0114 0.0052 0.0052
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 1.4439 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0114 0.0052 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0114 0.0052 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 0.5
Loa Loa (eye worm) hypothetical protein 0.0114 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0132 0.0065 0.0041
Echinococcus granulosus neuropeptide receptor 0.0132 0.0065 0.0041
Brugia malayi neuropeptide F receptor 0.0132 0.0065 0.0065
Echinococcus granulosus g protein coupled receptor 0.0132 0.0065 0.0041
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0078 0.0028 0.0026
Onchocerca volvulus 0.0132 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Brugia malayi putative neuropeptide receptor 0.0132 0.0065 0.0065
Schistosoma mansoni amine GPCR 0.0132 0.0065 0.0065
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0132 0.0065 0.0065
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0132 0.0065 0.0065
Echinococcus multilocularis neuropeptide receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis g protein coupled receptor 0.0132 0.0065 0.0065
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0051 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis expressed conserved protein 0.0073 0.0024 0.0024
Brugia malayi hypothetical protein 0.0187 0.0103 0.0103
Onchocerca volvulus 0.0132 0.0065 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0114 0.0052 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.0065 0.0041
Echinococcus multilocularis allatostatin A receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus 7tm_1 domain containing protein 0.0132 0.0065 0.0041
Echinococcus granulosus alpha 16 mannosyl glycoprotein 1.4439 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0641 0.0419 0.0419
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Echinococcus multilocularis G-protein coupled receptor, putative 0.0132 0.0065 0.0065
Echinococcus multilocularis g protein coupled receptor 0.0132 0.0065 0.0065
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.0318 0.0294
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0132 0.0065 0.0065
Echinococcus granulosus g protein coupled receptor 0.0132 0.0065 0.0041
Schistosoma mansoni neuropeptide receptor 0.0132 0.0065 0.0065
Echinococcus multilocularis g-protein coupled receptor 0.0132 0.0065 0.0065
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0132 0.0065 0.0065
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0132 0.0065 0.0041
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.0065 0.0041
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus fmrfamide receptor 0.0132 0.0065 0.0041
Brugia malayi GnHR receptor homolog 0.0132 0.0065 0.0065
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0132 0.0065 0.0063
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.0065 0.0065
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0132 0.0065 0.0041
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Schistosoma mansoni amine GPCR 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.0065 0.0065
Schistosoma mansoni growth hormone secretagogue receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0078 0.0028 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.0065 0.0063
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0132 0.0065 0.0063
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Brugia malayi Serotonin receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0254 0.015 0.0148
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0132 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0132 0.0065 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis orexin receptor type 2 0.0132 0.0065 0.0065
Schistosoma mansoni myosin xvIII 0.0132 0.0065 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.0065 0.0065
Brugia malayi Dopamine receptor 0.0132 0.0065 0.0065
Schistosoma mansoni neuropeptide receptor 0.0132 0.0065 0.0065
Schistosoma mansoni histamine h1 receptor 0.0132 0.0065 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Brugia malayi ORL1-like opioid receptor 0.0132 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.0065 0.0065
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0132 0.0065 0.0065
Echinococcus granulosus somatostatin receptor 0.0132 0.0065 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.0065 0.0041
Brugia malayi putative neuropeptide receptor NPR1 0.0132 0.0065 0.0065
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0132 0.0065 0.0065
Brugia malayi hypothetical protein 0.0132 0.0065 0.0065
Schistosoma mansoni opsin-like receptor 0.0132 0.0065 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.0065 0.0065
Schistosoma mansoni adenoreceptor 0.0132 0.0065 0.0065
Schistosoma mansoni amine GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis sex peptide receptor 0.0132 0.0065 0.0065
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0074 0.0025 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.0065 0.0041
Echinococcus multilocularis peptidase Clp (S14 family) 0.0074 0.0025 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.0065 0.0063
Brugia malayi G protein-coupled receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) melatonin receptor type 1A 0.0132 0.0065 0.0063
Onchocerca volvulus 0.0132 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus peptide allatostatin:somatostatin 0.0132 0.0065 0.0041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.0065 0.0065
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0132 0.0065 0.0065
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 0.5
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0114 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus multilocularis serotonin receptor 0.0254 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Echinococcus granulosus hypothetical protein 0.0132 0.0065 0.0041
Echinococcus multilocularis neuropeptide receptor 0.0132 0.0065 0.0065
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0132 0.0065 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0132 0.0065 0.0063
Schistosoma mansoni biogenic amine receptor 0.0132 0.0065 0.0065
Brugia malayi G protein-coupled receptor F59B2.13 0.0132 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.0065 0.0065
Echinococcus multilocularis Niemann Pick C1 protein 0.0078 0.0028 0.0028
Echinococcus multilocularis somatostatin receptor 0.0132 0.0065 0.0065
Brugia malayi Serotonin receptor 0.0132 0.0065 0.0065
Onchocerca volvulus 0.0132 0.0065 1
Brugia malayi Dopamine receptor protein 1 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063
Onchocerca volvulus 0.0132 0.0065 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0132 0.0065 0.0041
Schistosoma mansoni neuropeptide receptor 0.0132 0.0065 0.0065
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.0065 0.0065
Echinococcus multilocularis dro:myosuppressin receptor 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0254 0.015 0.0148
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.0065 0.0041
Brugia malayi sulfakinin receptor protein 0.0132 0.0065 0.0065
Schistosoma mansoni amine GPCR 0.426 0.2932 0.2932
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.0065 0.0065
Brugia malayi AKH receptor 0.0132 0.0065 0.0065
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0132 0.0065 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.0065 0.0065
Schistosoma mansoni amine GPCR 0.0132 0.0065 0.0065
Brugia malayi follicle stimulating hormone receptor 0.0132 0.0065 0.0065
Echinococcus granulosus neuropeptide FF receptor 2 0.0132 0.0065 0.0041
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0132 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0132 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0065 0.0063

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 25 ug ml-1 Antimicrobial activity against Candida albicans ATCC 10231 by microbroth dilution assay ChEMBL. 23317013
MIC (functional) > 25 ug ml-1 Antimicrobial activity against Cryptococcus neoformans ATCC 66031 by microbroth dilution assay ChEMBL. 23317013
MIC (functional) > 25 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 by microbroth dilution assay ChEMBL. 23317013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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