Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0083 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0083 | 1 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0083 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0083 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2291 | 0.2291 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0083 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Trypanosoma cruzi | p450 reductase, putative | 0.0083 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2291 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0083 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0083 | 1 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.7709 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Leishmania major | p450 reductase, putative | 0.0083 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0083 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0083 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0083 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0083 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0083 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0083 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.7709 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.9 nM | Growth inhibition of mouse L1210 cells after 72 hrs by phosphatase assay | ChEMBL. | 24223237 |
IC50 (functional) | = 530 nM | Cytotoxicity against vinblastine-resistant human HCT116/VM46 cells after 72 hrs by phosphatase assay | ChEMBL. | 23244701 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 24223237 | |
Homo sapiens | ChEMBL23 | 23244701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.