Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0924 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0924 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0924 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0924 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0924 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0924 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0924 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0924 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0924 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0924 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0924 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0924 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as kidney damage at 1 to 500 mg/kg, ip for 14 days | ChEMBL. | 23279863 | |
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as liver damage at 1 to 500 mg/kg, ip for 14 days | ChEMBL. | 23279863 | |
Activity (ADMET) | Toxicity in C57BL/6 mouse assessed as heart damage at 1 to 500 mg/kg, ip for 14 days | ChEMBL. | 23279863 | |
IC50 (functional) | > 200 uM | Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay | ChEMBL. | 23279863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.