Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.1458 | 0 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.1458 | 0 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.3936 | 1 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.1458 | 0 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.1458 | 0 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.3936 | 1 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.3936 | 1 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.3936 | 1 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.1458 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.5 uM | In vitro inhibition of human recombinant IL-1beta-induced breakdown of bovine cartilage in a cartilage organ culture assay | ChEMBL. | 7932530 |
IC50 (functional) | = 62 uM | Tested for the inhibition of prostromelysin activation with no preincubation period | ChEMBL. | 7932530 |
IC50 (functional) | = 62 uM | Tested for the inhibition of prostromelysin activation with no preincubation period | ChEMBL. | 7932530 |
Inhibition (functional) | = 45 % | Tested for inhibition of stromelysin using [3H]transferrin, following preincubation of the compound with prostromelysin for 0 hr prior to activation by plasmin | ChEMBL. | 7932530 |
Inhibition (functional) | = 45 % | Tested for inhibition of stromelysin using [3H]transferrin, following preincubation of the compound with prostromelysin for 0 hr prior to activation by plasmin | ChEMBL. | 7932530 |
Inhibition (functional) | = 65 % | Tested for inhibition of stromelysin using [3H]transferrin, following preincubation of the compound with prostromelysin for 3 hr prior to activation by plasmin | ChEMBL. | 7932530 |
Inhibition (functional) | = 65 % | Tested for inhibition of stromelysin using [3H]transferrin, following preincubation of the compound with prostromelysin for 3 hr prior to activation by plasmin | ChEMBL. | 7932530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.