Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin E receptor 1 (subtype EP1) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 2 (subtype EP2) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Mus musculus | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Mus musculus | thromboxane A2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0808 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0258 | 0.2622 | 0.2622 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.032 | 0.345 | 0.3762 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0132 | 0.0935 | 0.0935 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0107 | 0.0587 | 0.0587 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0107 | 0.0587 | 0.0587 |
Schistosoma mansoni | tyrosine kinase | 0.0132 | 0.0935 | 0.1019 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0746 | 0.9172 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0073 | 0.0141 | 0.0177 |
Loa Loa (eye worm) | glutamate receptor | 0.0656 | 0.7965 | 0.7965 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.055 | 0.6535 | 0.7125 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1415 | 0.1415 |
Echinococcus granulosus | insulin receptor | 0.0132 | 0.0935 | 0.0935 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0132 | 0.0935 | 0.0935 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0132 | 0.0935 | 0.0935 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0126 | 0.0126 |
Schistosoma mansoni | tyrosine kinase | 0.0132 | 0.0935 | 0.1019 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0107 | 0.0587 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.055 | 0.6535 | 0.6535 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0656 | 0.7965 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0168 | 0.1415 | 0.1415 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0595 | 0.7137 | 0.896 |
Loa Loa (eye worm) | hypothetical protein | 0.0808 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0132 | 0.0935 | 0.0935 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0107 | 0.0587 | 0.0737 |
Brugia malayi | Protein kinase domain containing protein | 0.0132 | 0.0935 | 0.1174 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0168 | 0.1415 | 0.1777 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.032 | 0.345 | 0.4332 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0107 | 0.0587 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0168 | 0.1415 | 0.1415 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0587 | 0.064 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.055 | 0.6535 | 0.6535 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0587 | 0.0587 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 7157 ml/min.Kg | Intrinsic clearance in mouse liver microsomes | ChEMBL. | 23218714 |
Kd (binding) | = 6.35 | Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx | ChEMBL. | 23218714 |
Kd (binding) | = 447 nM | Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse TP receptor | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse EP4 receptor | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse EP3 receptor | ChEMBL. | 23218714 |
Ki (binding) | > 6 | Antagonist activity at mouse EP2 receptor | ChEMBL. | 23218714 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.