Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0063 | 0.2574 | 0.2574 |
Schistosoma mansoni | histone deacetylase | 0.0222 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0063 | 0.2574 | 0.2574 |
Brugia malayi | Histone deacetylase 1 | 0.0222 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.158 | 0.158 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | histone deacetylase | 0.0063 | 0.2574 | 0.2574 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.145 | 0.145 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2574 | 0.2574 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0222 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0063 | 0.2574 | 0.2574 |
Leishmania major | histone deacetylase, putative | 0.0222 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0222 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0063 | 0.2574 | 0.2574 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0222 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0222 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0181 | 0.0181 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.158 | 0.158 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0222 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0063 | 0.2574 | 0.2574 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0222 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0181 | 0.0181 |
Echinococcus granulosus | histone deacetylase 6 | 0.0063 | 0.2574 | 0.2574 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0063 | 0.2574 | 0.2574 |
Echinococcus multilocularis | histone deacetylase | 0.0063 | 0.2574 | 0.2574 |
Echinococcus granulosus | histone deacetylase 7 | 0.0063 | 0.2574 | 0.2574 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0222 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0222 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0222 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.0063 | 0.2574 | 0.2574 |
Schistosoma mansoni | histone deacetylase | 0.0222 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0222 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0222 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0063 | 0.2574 | 0.2574 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0063 | 0.2574 | 0.2574 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0181 | 0.0181 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0222 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0063 | 0.2574 | 0.2574 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0222 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0222 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0222 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0063 | 0.2574 | 0.2574 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0181 | 0.0181 |
Echinococcus granulosus | histone deacetylase 8 | 0.0063 | 0.2574 | 0.2574 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0222 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0063 | 0.2574 | 0.2574 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.1761 | 0.1761 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0063 | 0.2574 | 0.2574 |
Plasmodium falciparum | histone deacetylase 1 | 0.0222 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0222 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0181 | 0.0181 |
Echinococcus granulosus | histone deacetylase 3 | 0.0222 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0063 | 0.2574 | 0.2574 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.132 | 0.132 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.1761 | 0.1761 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0063 | 0.2574 | 0.2574 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.158 | 0.158 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.145 | 0.145 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0222 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0181 | 0.0181 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.158 | 0.158 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0063 | 0.2574 | 0.2574 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0222 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0222 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0181 | 0.0181 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0063 | 0.2574 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0063 | 0.2574 | 0.2574 |
Brugia malayi | histone deacetylase 11 | 0.0063 | 0.2574 | 0.2574 |
Trypanosoma brucei | histone deacetylase 1 | 0.0222 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 111 uM | Inhibition of recombinant Tdp1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine as substrate after 15 mins by PAGE analysis | ChEMBL. | 23259865 |
Inhibition (binding) | Inhibition of recombinant Top1 (unknown origin) using 3'-[32P]-end-labeled 117 bp oligonucleotide as substrate after 20 mins by SDS-PAGE analysis | ChEMBL. | 23259865 | |
Ratio (binding) | < 1 | Activation of human RXRalpha activity expressed in COS1 cells assessed as induction ratio at 50 uM after 12 hrs by RXRE-luciferase reporter gene assay relative to untreated control | ChEMBL. | 23472886 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.