Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 105 % | Agonist activity at VDR in human MG-63 cells assessed as transcriptional activation of osteopontin gene after 3 days by luciferase reporter gene assay relative to 1,25(OH)2D3 | ChEMBL. | 23266184 |
Activity (functional) | = 126 % | Induction of human HL60 cell differentiation after 4 days by WST-8 assay relative to 1.25-OH2 D3 | ChEMBL. | 23266184 |
Activity (binding) | = 447 % | Agonist activity at VDR in human MG-63 cells assessed as osteocalcin production compound incubated for 8 hrs measured after 4 days by EIA relative to 1,25(OH)2D3 | ChEMBL. | 23266184 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.