Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | unspecified product | 1.9108 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 1.0637 | 0.4706 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 1.9108 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 1.9108 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 1.0637 | 0.4706 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Giardia lamblia | Casein kinase II beta chain | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Leishmania major | casein kinase II, putative | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Schistosoma mansoni | protein kinase | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Echinococcus granulosus | casein kinase ii subunit alpha | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 1.0637 | 0.4706 | 0.4706 |
Trypanosoma brucei | Casein kinase II | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Loa Loa (eye worm) | Csnk2b protein | 1.0637 | 0.4706 | 0.4706 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 1.9108 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 1.9108 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 1.9108 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 1.9108 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 1.0637 | 0.4706 | 0.4706 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 1.9108 | 1 | 1 |
Brugia malayi | Csnk2b protein | 1.0637 | 0.4706 | 0.4706 |
Entamoeba histolytica | protein kinase domain containing protein | 1.9108 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (functional) | = 92.2 % | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay relative to control | ChEMBL. | 23177787 |
EC50 (functional) | = 7.28 | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay | ChEMBL. | 23177787 |
EC50 (functional) | = 52 nM | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay | ChEMBL. | 23177787 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.