TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 578.557 | Formula: C24H21Cl2N5O2S3
H donors: 1 H acceptors: 3 LogP: 6.34 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)c1csc(n1)N1N=C(CC1c1ccc(cc1)N(C)C)c1cc(sc1S(=O)(=O)N)Cl
InChi: 1S/C24H21Cl2N5O2S3/c1-30(2)17-9-5-15(6-10-17)21-12-19(18-11-22(26)35-23(18)36(27,32)33)29-31(21)24-28-20(13-34-24)14-3-7-16(25)8-4-14/h3-11,13,21H,12H2,1-2H3,(H2,27,32,33)
InChiKey: ZURKKZUBCSLQKP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Xanthine dehydrogenase/oxidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	Get druggable targets OG5_127252	All targets in OG5_127252
Mycobacterium ulcerans	carbon monoxide dehydrogenase	Get druggable targets OG5_127252	All targets in OG5_127252
Trichomonas vaginalis	xanthine dehydrogenase, putative	Get druggable targets OG5_127252	All targets in OG5_127252
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	Get druggable targets OG5_127252	All targets in OG5_127252
Trichomonas vaginalis	xanthine dehydrogenase, putative	Get druggable targets OG5_127252	All targets in OG5_127252
Trichomonas vaginalis	aldehyde oxidase, putative	Get druggable targets OG5_127252	All targets in OG5_127252
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	Get druggable targets OG5_127252	All targets in OG5_127252

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	SH2 motif	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0273	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Onchocerca volvulus		0.0273	1	1
Toxoplasma gondii	protein kinase	0.0111	0.2339	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0273	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0162	0.472	0.3108
Echinococcus multilocularis	SH2 motif	0.0162	0.472	0.3108
Schistosoma mansoni	tensin-related	0.0162	0.472	0.3108
Echinococcus granulosus	growth factor receptor bound protein 2	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0162	0.472	0.3108
Loa Loa (eye worm)	SH2 domain-containing protein	0.0162	0.472	0.3108
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0273	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0162	0.472	0.3108
Brugia malayi	hypothetical protein	0.0273	1	1
Loa Loa (eye worm)	SRC-1	0.0273	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0162	0.472	0.3108
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0273	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0273	1	1
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0209	0.6981	1
Echinococcus multilocularis	tensin	0.0162	0.472	0.3108
Echinococcus multilocularis	SH2 domain containing protein 7	0.0162	0.472	0.3108
Echinococcus multilocularis	N chimaerin	0.0162	0.472	0.3108
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0162	0.472	0.3108
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0111	0.2339	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	suppressor of cytokine signaling	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0273	1	1
Onchocerca volvulus		0.0273	1	1
Echinococcus multilocularis		0.0162	0.472	0.3108
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0273	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0273	1	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	tensin-related	0.0162	0.472	0.3108
Schistosoma mansoni	shc transforming protein	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0273	1	1
Giardia lamblia	Kinase	0.0111	0.2339	0.5
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	growth factor receptor-bound protein	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0162	0.472	0.3108
Schistosoma mansoni	tyrosine kinase	0.0273	1	1
Loa Loa (eye worm)	hypothetical protein	0.0273	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0273	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0162	0.472	0.3108
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0162	0.472	0.3108
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0111	0.2339	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0273	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine kinase	0.0273	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0162	0.472	0.3108
Loa Loa (eye worm)	TK/ABL protein kinase	0.0273	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0273	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0162	0.472	0.3108
Schistosoma mansoni	tensin	0.0162	0.472	0.3108
Schistosoma mansoni	vav2	0.0162	0.472	0.3108
Trypanosoma brucei	protein kinase, putative	0.0111	0.2339	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0273	1	1
Onchocerca volvulus		0.0162	0.472	0.3108
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0273	1	1
Onchocerca volvulus		0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0273	1	1
Brugia malayi	Protein kinase domain containing protein	0.0273	1	1
Schistosoma mansoni	tyrosine kinase	0.0273	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0111	0.2339	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0162	0.472	0.3108
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0111	0.2339	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0162	0.472	0.3108
Plasmodium vivax	protein kinase, putative	0.0111	0.2339	0.5
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Echinococcus multilocularis	NCK adaptor protein	0.0162	0.472	0.3108
Schistosoma mansoni	hypothetical protein	0.0162	0.472	0.3108
Echinococcus granulosus	tensin	0.0162	0.472	0.3108
Giardia lamblia	Protein 21.1	0.0111	0.2339	0.5
Schistosoma mansoni	tensin	0.0162	0.472	0.3108
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Blk	0.0273	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0273	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0273	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0162	0.472	0.3108
Echinococcus multilocularis	tensin	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	tyrosine kinase	0.0273	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0162	0.472	0.3108
Brugia malayi	Protein kinase domain containing protein	0.0273	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0111	0.2339	0.5
Schistosoma mansoni	SH2A	0.0162	0.472	0.3108
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0162	0.472	0.3108
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0162	0.472	0.3108
Trypanosoma cruzi	protein kinase, putative	0.0111	0.2339	0.5
Echinococcus granulosus	NCK adaptor protein	0.0162	0.472	0.3108
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0099	0.1737	0.4783
Toxoplasma gondii	protein kinase domain-containing protein	0.0111	0.2339	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0273	1	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0273	1	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0111	0.2339	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0273	1	1
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0099	0.1737	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0273	1	1
Trichomonas vaginalis	aldehyde oxidase, putative	0.0209	0.6981	1
Entamoeba histolytica	protein kinase, putative	0.0162	0.472	0.3108
Onchocerca volvulus		0.0162	0.472	0.3108
Echinococcus multilocularis	signal transduction protein lnk realted	0.0162	0.472	0.3108
Schistosoma mansoni	tyrosine kinase	0.0273	1	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	adapter molecule crk	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Brugia malayi	hypothetical protein	0.0162	0.472	0.3108
Onchocerca volvulus		0.0273	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0162	0.472	0.3108
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0162	0.472	0.3108
Schistosoma mansoni	tyrosine kinase	0.0273	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0273	1	1
Leishmania major	hypothetical protein, conserved	0.0111	0.2339	0.5
Trypanosoma cruzi	protein kinase, putative	0.0111	0.2339	0.5
Echinococcus granulosus	tyrosine kinase	0.0273	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0111	0.2339	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0162	0.472	0.3108
Echinococcus granulosus	SHC transforming protein 3	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0273	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0111	0.2339	0.5
Echinococcus granulosus	N chimaerin	0.0162	0.472	0.3108
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0162	0.472	0.3108
Plasmodium falciparum	tyrosine kinase-like protein	0.0111	0.2339	0.5
Toxoplasma gondii	STE kinase	0.0111	0.2339	0.5
Onchocerca volvulus		0.0273	1	1
Giardia lamblia	Kinase, NEK	0.0111	0.2339	0.5
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0099	0.1737	0.4783
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0162	0.472	0.3108
Loa Loa (eye worm)	SH2 domain-containing protein	0.0162	0.472	0.3108
Brugia malayi	SRC-1	0.0273	1	1
Brugia malayi	RhoGAP domain containing protein	0.0162	0.472	0.3108
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0273	1	1
Leishmania major	protein kinase, putative	0.0111	0.2339	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0111	0.2339	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0162	0.472	0.3108
Giardia lamblia	Kinase, NEK	0.0111	0.2339	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0273	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Onchocerca volvulus		0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0273	1	1
Brugia malayi	protein-tyrosine kinase	0.0273	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0162	0.472	0.3108
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0111	0.2339	0.5
Echinococcus granulosus	hypothetical protein	0.0162	0.472	0.3108
Echinococcus multilocularis	SH2 motif	0.0162	0.472	0.3108
Onchocerca volvulus		0.0162	0.472	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Brugia malayi	Tensin	0.0162	0.472	0.3108
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0273	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0162	0.472	0.3108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0273	1	1
Onchocerca volvulus		0.0273	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine kinase	0.0273	1	1
Plasmodium falciparum	protein kinase, putative	0.0111	0.2339	0.5
Brugia malayi	Protein kinase domain containing protein	0.0273	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0162	0.472	0.3108
Schistosoma mansoni	nck2/grb4	0.0162	0.472	0.3108
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0209	0.6981	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0162	0.472	0.3108
Brugia malayi	SH2 domain containing protein	0.0273	1	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.472	0.3108
Plasmodium falciparum	protein kinase, putative	0.0111	0.2339	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Brugia malayi	Protein kinase domain containing protein	0.0273	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0273	1	1
Echinococcus granulosus	expressed conserved protein	0.0162	0.472	0.3108
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0111	0.2339	0.5
Leishmania major	protein kinase, putative	0.0111	0.2339	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0111	0.2339	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	1	1
Echinococcus granulosus	SH2 motif	0.0162	0.472	0.3108
Echinococcus granulosus	tyrosine protein kinase Srms	0.0273	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0273	1	1
Schistosoma mansoni	tyrosine kinase	0.0273	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0273	1	1
Onchocerca volvulus		0.0162	0.472	0.3108
Loa Loa (eye worm)	TK protein kinase	0.0273	1	1
Loa Loa (eye worm)	STAT protein	0.0162	0.472	0.3108
Onchocerca volvulus		0.0273	1	1
Plasmodium falciparum	protein kinase, putative	0.0111	0.2339	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0273	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0273	1	1
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0071	0.0409	0.1125
Brugia malayi	Variant SH3 domain containing protein	0.0162	0.472	0.3108
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0162	0.472	0.3108
Echinococcus multilocularis	SHC transforming protein 3	0.0162	0.472	0.3108
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0071	0.0409	0.1125
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0273	1	1
Schistosoma mansoni	GTPase activating protein	0.0162	0.472	0.3108
Echinococcus multilocularis	SH2 motif	0.0162	0.472	0.3108
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0273	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0273	1	1
Brugia malayi	SH2 domain containing protein	0.0162	0.472	0.3108
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0162	0.472	0.3108
Brugia malayi	Variant SH3 domain containing protein	0.0162	0.472	0.3108
Schistosoma mansoni	hypothetical protein	0.0162	0.472	0.3108
Schistosoma mansoni	tensin	0.0162	0.472	0.3108
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0139	0.3631	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0162	0.472	0.3108

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.3 uM	Inhibition of Wistar albino rat xanthine oxidase isolated from liver using xanthine as substrate incubated for 15 mins prior to substrate addition by spectrophotometric analysis	ChEMBL.	23177727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2313041

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1738803