Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.047 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0334 | 0.5922 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0334 | 0.5922 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.047 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.047 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.047 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0334 | 0.5922 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0334 | 0.5922 | 1 |
Onchocerca volvulus | 0.0334 | 0.5922 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0136 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0159 | 0.068 | 0.1148 |
Echinococcus multilocularis | thymidylate synthase | 0.0334 | 0.5922 | 1 |
Brugia malayi | hypothetical protein | 0.0159 | 0.068 | 0.1148 |
Brugia malayi | thymidylate synthase | 0.0334 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.047 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 0.068 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0334 | 0.5922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 40 uM | Cytotoxicity against human HepG2 cells | ChEMBL. | 23237840 |
MIC (functional) | = 46 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv CNCTC My 331/88 after 10 to 14 days by microdilution panel method | ChEMBL. | 23237840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.