Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0331 | 0.5185 | 1 |
Mycobacterium ulcerans | ATPase | 0.0338 | 0.5325 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0536 | 0.9401 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0536 | 0.9401 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0536 | 0.9401 | 0.9401 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0338 | 0.5325 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0536 | 0.9401 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0565 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0536 | 0.9401 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.0331 | 0.5185 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0565 | 1 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0234 | 0.3172 | 0.6117 |
Brugia malayi | valosin containing protein | 0.0331 | 0.5185 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0565 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0234 | 0.3172 | 0.3172 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0565 | 1 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0536 | 0.9401 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.5185 | 1 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0234 | 0.3172 | 0.6117 |
Trypanosoma brucei | Valosin-containing protein | 0.0536 | 0.9401 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0338 | 0.5325 | 0.0000097958 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0234 | 0.3172 | 0.3172 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0536 | 0.9401 | 1 |
Giardia lamblia | AAA family ATPase | 0.0338 | 0.5325 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0565 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.61 uM | Growth inhibition of human SF539 cells | ChEMBL. | 23259865 |
IC50 (binding) | = 15 uM | Inhibition of recombinant Tdp1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine as substrate after 15 mins by PAGE analysis | ChEMBL. | 23259865 |
Inhibition (binding) | Inhibition of recombinant Top1 (unknown origin) using 3'-[32P]-end-labeled 117 bp oligonucleotide as substrate after 20 mins by SDS-PAGE analysis relative to 1 uM MJ-3-65 | ChEMBL. | 23259865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.