Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.5809 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.3243 | 0.5534 | 0.5534 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3243 | 0.5534 | 0.4721 |
Loa Loa (eye worm) | Csnk2b protein | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.5809 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.3243 | 0.5534 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Leishmania major | casein kinase II, putative | 0.5809 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.5809 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.5809 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.3243 | 0.5534 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.5809 | 1 | 1 |
Toxoplasma gondii | ck2 beta subunit | 0.3243 | 0.5534 | 0.5534 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Schistosoma mansoni | protein kinase | 0.5809 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3243 | 0.5534 | 0.4721 |
Giardia lamblia | Kinase, CMGC CK2 | 0.5809 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.5809 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Schistosoma mansoni | casein kinase II beta subunit | 0.3243 | 0.5534 | 0.5534 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.3243 | 0.5534 | 0.5534 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Leishmania major | protein kinase ck2 regulatory subunit, putative | 0.3243 | 0.5534 | 0.5534 |
Brugia malayi | Csnk2b protein | 0.3243 | 0.5534 | 0.4721 |
Entamoeba histolytica | protein kinase domain containing protein | 0.5809 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.5809 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.5809 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.5809 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.5809 | 1 | 1 |
Toxoplasma gondii | casein kinase ii regulatory subunit protein | 0.3243 | 0.5534 | 0.5534 |
Trichomonas vaginalis | CMGC family protein kinase | 0.5809 | 1 | 1 |
Giardia lamblia | Casein kinase II beta chain | 0.3243 | 0.5534 | 0.4721 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3243 | 0.5534 | 0.4721 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 6 % | Inhibition of Wnt/beta-catenin in human HCT116 cells assessed as remaining cytosolic beta-catenin level at 2 uM after 18 hrs by Western blot analysis relative to control | ChEMBL. | 26272032 |
IC50 (binding) | = 0.56 uM | Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs | ChEMBL. | 26272032 |
MIC (functional) | = 0.8 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC27294 assessed as complete cessation of growth | ChEMBL. | 23211970 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 26272032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.