Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0026 | 0.5 | 0.5 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0026 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0026 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0026 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0026 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0026 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0026 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0026 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0026 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0026 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.11 nM | Displacement of [125I]PYY from mouse NPY-Y5 receptor | ChEMBL. | 23206862 |
INH (ADMET) | > 20 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 23206862 |
INH (ADMET) | > 20 uM | Inhibition of CYP2D6 (unknown origin) | ChEMBL. | 23206862 |
INH (ADMET) | > 20 uM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 23206862 |
INH (ADMET) | > 20 uM | Inhibition of CYP2C19 (unknown origin) | ChEMBL. | 23206862 |
INH (ADMET) | > 20 uM | Inhibition of CYP1A2 (unknown origin) | ChEMBL. | 23206862 |
Stabilty (ADMET) | = 86.2 % | Metabolic stability in mouse liver microsomes assessed as compound remaining after 30 mins | ChEMBL. | 23206862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.