Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0043 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0043 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0043 | 0.5 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0043 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0043 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0043 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 6 | 0.0404 | 0.4236 | 0.4212 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0404 | 0.4236 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0043 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0911 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0043 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0911 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0911 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0043 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0043 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 6 | 0.0404 | 0.4236 | 0.4212 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0043 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0043 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of BF3 site of androgen receptor in human LNCAP cells expressing ARR2PB after 3 days by eGFP transcriptional assay | ChEMBL. | 23301637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.